Monday Lecture Series
(open to the Rockefeller community)
Monday, January 30th, 2023
Sanford Simon, Ph.D.
Günter Blobel Professor,
Head of the Laboratory of Cellular BioPhysics,
The Rockefeller University
Fighting Rare Cancers: Lessons from Fibrolamellar Hepatocellular Carcinoma
Recommended Readings:
Empirical Articles
Neumayer, C., Ng, D., Jiang, C. S., Qureshi, A., Lalazar, G., Vaughan, R., & Simon, S. M. (2023). Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA. Clinical cancer research : an official journal of the American Association for Cancer Research, 29(1), 271–278.
Berkovitz, A., Migler, R. D., Qureshi, A., Rosemore, C., Torbenson, M. S., Vaughan, R., Marcotte, E., & Simon, S. M. (2022). Clinical and demographic predictors of survival for fibrolamellar carcinoma patients-A patient community, registry-based study. Hepatology communications, 6(12), 3539–3549.
Shebl, B., Ng, D., Lalazar, G., Rosemore, C., Finkelstein, T. M., Migler, R. D., Zheng, G., Zhang, P., Jiang, C. S., Qureshi, A., Vaughan, R., Yarchoan, M., de Jong, Y. P., Rice, C. M., Coffino, P., Ortiz, M. V., Zhou, D., & Simon, S. M. (2022). Targeting BCL-XL in fibrolamellar hepatocellular carcinoma. JCI insight, 7(17), e161820.
Narayan, N. J. C., Requena, D., Lalazar, G., Ramos-Espiritu, L., Ng, D., Levin, S., Shebl, B., Wang, R., Hammond, W. J., Saltsman, J. A., 3rd, Gehart, H., Torbenson, M. S., Clevers, H., LaQuaglia, M. P., & Simon, S. M. (2022). Human liver organoids for disease modeling of fibrolamellar carcinoma. Stem cell reports, 17(8), 1874–1888.
Lalazar, G., Requena, D., Ramos-Espiritu, L., Ng, D., Bhola, P. D., de Jong, Y. P., Wang, R., Narayan, N. J. C., Shebl, B., Levin, S., Michailidis, E., Kabbani, M., Vercauteren, K. O. A., Hurley, A. M., Farber, B. A., Hammond, W. J., Saltsman, J. A., 3rd, Weinberg, E. M., Glickman, J. F., Lyons, B. A., … Simon, S. M. (2021). Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient-Derived Xenografts and Direct-from-Patient Screening. Cancer discovery, 11(10), 2544–2563.
