Friday Lecture Series
(open to the Rockefeller community)
Friday, November 11, 2022
Nils-Göran Larsson, M.D., Ph.D.
Professor and Senior Consultant,
Department of Medical Biochemistry and Biophysics (MBB),
Karolinska Institutet
Center for Inherited Metabolic Diseases (CMMS),
Karolinska University Hospital,
Stockholm, Sweden
Inhibition of Mitochondrial DNA Transcription to Treat Cancer and Metabolic Disease
Recommended Readings:
Empirical Articles
Rubalcava-Gracia, D., García-Villegas, R., & Larsson, N. G. (2022). No role for nuclear transcription regulators in mammalian mitochondria?. Molecular cell, S1097-2765(22)00899-1.
Misic, J., Milenkovic, D., Al-Behadili, A., Xie, X., Jiang, M., Jiang, S., Filograna, R., Koolmeister, C., Siira, S. J., Jenninger, L., Filipovska, A., Clausen, A. R., Caporali, L., Valentino, M. L., La Morgia, C., Carelli, V., Nicholls, T. J., Wredenberg, A., Falkenberg, M., & Larsson, N. G. (2022). Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion. Nucleic acids research, 50(15), 8749–8766.
Milenkovic, D., Sanz-Moreno, A., Calzada-Wack, J., Rathkolb, B., Veronica Amarie, O., Gerlini, R., Aguilar-Pimentel, A., Misic, J., Simard, M. L., Wolf, E., Fuchs, H., Gailus-Durner, V., de Angelis, M. H., & Larsson, N. G. (2022). Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction. PLoS genetics, 18(5), e1010190.
Mennuni, M., Filograna, R., Felser, A., Bonekamp, N. A., Giavalisco, P., Lytovchenko, O., & Larsson, N. G. (2022). Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR-Cas9 screen. EMBO reports, 23(1), e53054.
Jiang, M., Xie, X., Zhu, X., Jiang, S., Milenkovic, D., Misic, J., Shi, Y., Tandukar, N., Li, X., Atanassov, I., Jenninger, L., Hoberg, E., Albarran-Gutierrez, S., Szilagyi, Z., Macao, B., Siira, S. J., Carelli, V., Griffith, J. D., Gustafsson, C. M., Nicholls, T. J., Filipovska, A., Larsson, N. G., & Falkenberg, M. (2021). The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication. Science advances, 7(27), eabf8631.
