Monday Lecture Series
(open to the Rockefeller community)
Monday, February 13, 2023
Jeffrey V. Ravetch, M.D., Ph.D.
Theresa and Eugene M. Lang Professor,
Head of the Leonard Wagner Laboratory of Molecular Genetics and Immunology,
The Rockefeller University
Diversity of Antibody Effector Functions
Recommended Readings:
Empirical Articles
Kao, K. S., Gupta, A., Zong, G., Li, C., Kerschbaumer, I., Borghi, S., Achkar, J. M., Bournazos, S., Wang, L. X., & Ravetch, J. V. (2022). Synthetic nanobodies as tools to distinguish IgG Fc glycoforms. Proceedings of the National Academy of Sciences of the United States of America, 119(48), e2212658119.
Gupta, A., Smith, P., Bournazos, S., & Ravetch, J. V. (2022). A novel mouse strain optimized for chronic human antibody administration. Proceedings of the National Academy of Sciences of the United States of America, 119(10), e2123002119.
Yamin, R., Jones, A. T., Hoffmann, H. H., Schäfer, A., Kao, K. S., Francis, R. L., Sheahan, T. P., Baric, R. S., Rice, C. M., Ravetch, J. V., & Bournazos, S. (2021). Fc-engineered antibody therapeutics with improved anti-SARS-CoV-2 efficacy. Nature, 599(7885), 465–470.
Li, C., Chong, G., Zong, G., Knorr, D. A., Bournazos, S., Aytenfisu, A. H., Henry, G. K., Ravetch, J. V., MacKerell, A. D., Jr, & Wang, L. X. (2021). Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity. Journal of the American Chemical Society, 143(20), 7828–7838.
Nimmerjahn, F., & Ravetch, J. V. (2021). Four keys to unlock IgG. The Journal of experimental medicine, 218(3), e20201753.
