Friday Lecture Series
(open to the Rockefeller community)
Friday, April 8, 2022
Lalita Ramakrishnan, MBBS, Ph.D.
Professor of Immunology and Infectious Diseases,
Head of the Molecular Immunity Unit
Centre for Therapeutic Immunology and Infectious Diseases, Department of Medicine
University of Cambridge
Group Leader, Cell Biology Division, MRC Laboratory of Molecular Biology
Cambridge, UK
A Zebrafish Guide to Tuberculosis Pathogenesis and Treatment
Recommended Readings:
Empirical Articles
Osman, M. M., Shanahan, J. K., Chu, F., Takaki, K. K., Pinckert, M. L., Pagán, A. J., Brosch, R., Conrad, W. H., & Ramakrishnan, L. (2022). The C terminus of the mycobacterium ESX-1 secretion system substrate ESAT-6 is required for phagosomal membrane damage and virulence. Proceedings of the National Academy of Sciences of the United States of America, 119(11), e2122161119.
Behr, M. A., Kaufmann, E., Duffin, J., Edelstein, P. H., & Ramakrishnan, L. (2021). Latent Tuberculosis: Two Centuries of Confusion. American journal of respiratory and critical care medicine, 204(2), 142–148.
Osman, M.M., Pinckert, M.L., Peak-Chew, S., Troll, M.A., Conrad, W.H., & Ramakrishnan, L. (2021) Ebselen attenuates mycobacterial virulence through inhibition of ESX-1 secretion. bioRxiv 828574
Behr, M. A., Edelstein, P. H., & Ramakrishnan, L. (2020). SLeuthing Tuberculous Cough. Cell, 181(2), 230–232.
Roca, F. J., Whitworth, L. J., Redmond, S., Jones, A. A., & Ramakrishnan, L. (2019). TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Cell, 178(6), 1344–1361.e11.
