Friday Lecture Series
(open to the Tri-I community)
Friday, February 3, 2023
Michael T. Laub, Ph.D.
Professor,
Department of Biology,
Massachusetts Institute of Technology,
Cambridge, MA
Investigator,
Howard Hughes Medical Institute
New Players in the Molecular Arms Race Between Bacteria and Phages
Recommended Readings:
Empirical Articles
Zhang, T., Tamman, H., Coppieters ‘t Wallant, K., Kurata, T., LeRoux, M., Srikant, S., Brodiazhenko, T., Cepauskas, A., Talavera, A., Martens, C., Atkinson, G. C., Hauryliuk, V., Garcia-Pino, A., & Laub, M. T. (2022). Direct activation of a bacterial innate immune system by a viral capsid protein. Nature, 612(7938), 132–140.
Gozzi, K., Tran, N. T., Modell, J. W., Le, T. B. K., & Laub, M. T. (2022). Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase. PLoS biology, 20(11), e3001790.
Vassallo, C. N., Doering, C. R., Littlehale, M. L., Teodoro, G. I. C., & Laub, M. T. (2022). A functional selection reveals previously undetected anti-phage defence systems in the E. coli pangenome. Nature microbiology, 7(10), 1568–1579.
Srikant, S., Guegler, C. K., & Laub, M. T. (2022). The evolution of a counter-defense mechanism in a virus constrains its host range. eLife, 11, e79549.
LeRoux, M., Srikant, S., Teodoro, G. I. C., Zhang, T., Littlehale, M. L., Doron, S., Badiee, M., Leung, A. K. L., Sorek, R., & Laub, M. T. (2022). The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA. Nature microbiology, 7(7), 1028–1040.
