Friday Lectures
Friday, March 6, 2020 3:45 p.m.
Caspary Auditorium
Rochelle Buffenstein, Ph.D.
Senior Principal Investigator
Calico
Breaking the Mold; Insights into Aging from the Long-lived Cancer-resistant Naked Mole-Rat
Recommended Readings:
Science News
Kai Kupferschmidt. Naked mole rats defy the biological law of aging. January 26, 2018. Science magazine
Empirical Articles
Hilton, Hugo G.; Rubinstein, Nimrod D.; Janki, Peter; et al. (2019). Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity. PLOS BIOLOGY. 17 (11)
Ruby, J. Graham; Smith, Megan; Buffenstein, Rochelle. (2018). Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age. ELIFE. 7
Rodriguez, Karl A.; Valentine, Joseph M.; Kramer, David A.; et al. (2016). Determinants of rodent longevity in the chaperone-protein degradation network. CELL STRESS & CHAPERONES. 21 (3): 453-466
Kim, Eun Bae; Fang, Xiaodong; Fushan, Alexey A.; et al. (2011). Genome sequencing reveals insights into physiology and longevity of the naked mole rat. NATURE. 479 (7372): 223-227
Perez, Viviana I.; Buffenstein, Rochelle; Masamsetti, Venkata; et al. (2009). Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. PNAS. 106 (9): 3059-3064
Buffenstein, R. (2005). The naked mole-rat? A new long-living model for human aging research. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 60 (11): 1369-1377
Review Papers
Lewis, Kaitlyn N.; Soifer, Ilya; Melamud, Eugene; et al. (2016). Unraveling the message: insights into comparative genomics of the naked mole-rat. MAMMALIAN GENOME. 27 (7-8): 259-278
Lewis, Kaitlyn N.; Andziak, Blazej; Yang, Ting; et al. (2013). The Naked Mole-Rat Response to Oxidative Stress: Just Deal with It. ANTIOXIDANTS & REDOX SIGNALING. 19 (12): 1388-1399
Book Chapter
Buffenstein, Rochelle; Park, Thomas; Hanes, Martha; et al. (2012). Naked Mole Rat. LABORATORY RABBIT, GUINEA PIG, HAMSTER, AND OTHER RODENTS. 1055-1074