Friday, March 13, 2020 3:45 p.m.
Ramanujan Hegde, Ph.D.
Laboratory of Molecular Biology
MRC – University of Cambridge, UK
Mechanisms of Multi-pass Membrane Protein Biogenesis
Volkmar, Norbert; Thezenas, Maria-Laetitia; Louie, Sharon M.; et al. (2019). The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. JOURNAL OF CELL SCIENCE. 132 (2)
Zavodszky, E. and Hegde, R. S. (2019). Misfolded GPI-anchored proteins are escorted throughthe secretory pathway by ER-derived factors. Elife
Chitwood, Patrick J.; Juszkiewicz, Szymon; Guna, Alina; et al. (2018). EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. CELL. 175 (6): 1507-+
Chen, Changchun; Itakura, Eisuke; Weber, Katherine P.; et al. (2014). An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism. PLOS GENETICS. 10 (3)
Satpute-Krishnan, Prasanna; Ajinkya, Monica; Bhat, Savithri; et al. (2014). ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway. CELL. 158 (3): 522-533
Hessa, Tara; Sharma, Ajay; Mariappan, Malaiyalam; et al. (2011). Protein targeting and degradation are coupled for elimination of mislocalized proteins. NATURE. 475 (7356): 394-U154
Guna, Alina; Hegde, Ramanujan S. (2018). Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. CURRENT BIOLOGY. 28 (8): R498-R511
Hegde, Ramanujan S.; Keenan, Robert J. (2011). Tail-anchored membrane protein insertion into the endoplasmic reticulum. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 12 (12): 787-798