Recommended Readings: Ramanujan Hegde, Ph.D., March 13, 2020

Recommended Readings: Ramanujan Hegde, Ph.D., March 13, 2020

Friday LecturesRamanujan Hegde, Ph.D.

Friday, March 13, 2020  3:45 p.m.

Caspary Auditorium

Ramanujan Hegde, Ph.D.

Group Leader

Laboratory of Molecular Biology

MRC – University of Cambridge, UK

Mechanisms of Multi-pass Membrane Protein Biogenesis


Recommended Readings:

Empirical Articles

Volkmar, Norbert; Thezenas, Maria-Laetitia; Louie, Sharon M.; et al. (2019). The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. JOURNAL OF CELL SCIENCE. 132 (2)

Zavodszky, E. and Hegde, R. S. (2019). Misfolded GPI-anchored proteins are escorted throughthe secretory pathway by ER-derived factors. Elife

Chitwood, Patrick J.; Juszkiewicz, Szymon; Guna, Alina; et al. (2018). EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. CELL. 175 (6): 1507-+

Chen, Changchun; Itakura, Eisuke; Weber, Katherine P.; et al. (2014). An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism. PLOS GENETICS. 10 (3)

Satpute-Krishnan, Prasanna; Ajinkya, Monica; Bhat, Savithri; et al. (2014). ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway. CELL. 158 (3): 522-533

Hessa, Tara; Sharma, Ajay; Mariappan, Malaiyalam; et al. (2011). Protein targeting and degradation are coupled for elimination of mislocalized proteins. NATURE. 475 (7356): 394-U154

Review Papers

Guna, Alina; Hegde, Ramanujan S. (2018). Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. CURRENT BIOLOGY. 28 (8): R498-R511

Hegde, Ramanujan S.; Keenan, Robert J. (2011). Tail-anchored membrane protein insertion into the endoplasmic reticulum. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 12 (12): 787-798

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About the Author:

Ilaria Ceglia, Ph.D., Science Informationist - Ilaria joined the Markus Library Team in 2017. As science liaison between the Rockefeller scientific community and the library, Ilaria assists Rockefeller scientists find, and effectively use, the scholarly communication tools available at the library, provides customized literature searching, delivers research information reports and publications metric analysis to enhance collaborations between Rockefeller and leading scientific institutions, provides access to digital content to manage large data freely accessible. Ilaria manages a drug development database to perform clinical literature searches and drugs pipeline reports for Rockefeller research faculty, scientists and clinicians. As the NIH compliance monitor for the Rockefeller University, Ilaria helps faculty to solve scientific submission requirements issues and ensures Rockefeller remains compliant with NIH Public Access Policy. Her role also includes evaluate and select new databases to complement other resource center services, organize tutorial training sessions in areas of life sciences and on the use of reference management platforms F1000 Workspace, Scopus, Web of Science and PubMed literature searching, managing recommendation readings library blog for lectures and special seminars. Ilaria is a neuroscientist and a former Rockefeller postdoctoral and research associate of Dr. Paul Greengard’s laboratory. She was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai, New York and an Adjunct Assistant Professor at City College and Hunter College in New York, where she taught Cell Biology and Biochemistry. As an Italian expat living in New York, Ilaria is an enthusiastic proponent of Italian culture among friends and colleagues.