Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, September 25, 2026
Bruce Spiegelman, Ph.D.
Professor of Cell Biology, Harvard Medical School; Stanley J. Korsmeyer Professor of Cell Biology and Medicine, Dana-Farber Cancer Institute
Regulation of Systemic Metabolism Through Adipose Bioenergetics and Thermogenesis
Recommended Readings:
Zammit, Nathan W., et al. “Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ–producing lymphocytes.” Science immunology 10.109 (2025): eads0478.
Vargas-Castillo, Ariana, et al. “Development of a functional beige fat cell line uncovers independent subclasses of cells expressing UCP1 and the futile creatine cycle.” Cell metabolism 36.9 (2024): 2146-2155.
Wang, Tongtong, et al. “Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes.” Cell metabolism 36.9 (2024): 2130-2145.
Chouchani, Edward T., Lawrence Kazak, and Bruce M. Spiegelman. “New advances in adaptive thermogenesis: UCP1 and beyond.” Cell metabolism 29.1 (2019): 27-37.
Kazak, Lawrence, et al. “A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.” Cell 163.3 (2015): 643-655.
