Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 29, 2026
Cigall Kadoch, Ph.D.
Professor and Meredith and Billy Starr Investigator, Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School; Institute Member and Epigenomics Program Co-director, Broad Institute of MIT and Harvard; Investigator, Howard Hughes Medical Institute
Structure and Function of Mammalian SWI/SNF Chromatin Remodeling Complexes in Human Health and Disease
Recommended Readings:
Jain, Siddhant U., et al. “A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform.” Science (2026): eaeb3627.
Gentile, Claudia, et al. “mSWI/SNF complex inhibition sensitizes KRAS-mutant lung cancers to targeted therapies via epithelial-mesenchymal subversion.” bioRxiv (2026): 2026-02.
St. Laurent, Jessica D., et al. “Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas.” Nature Genetics (2025): 1-13.
Pierre, Roodolph St, and Cigall Kadoch. “Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities.” Current opinion in genetics & development 42 (2017): 56-67.
Pulice, John L., and Cigall Kadoch. “Composition and function of mammalian SWI/SNF chromatin remodeling complexes in human disease.” Cold Spring Harbor symposia on quantitative biology. Vol. 81. Cold Spring Harbor Laboratory Press, 2016.
