Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

Friday Lectures

Friday, September 7, 2018  3:45 p.m.

Caspary Auditorium

John Hardy Ph.D. 

Head of the Department of Molecular Neuroscience

Chair of the Molecular Biology of Neurological Disease

University College London

Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders 

Recommended Readings:

Science News

Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today

Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM

Empirical Articles

Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7)860-875 

Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9)1373-+ 

Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071

Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9)989-+

Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358

Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)

Hardy, JDuff, KHardy, KGPerez-Tur, JHutton, M(1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358

Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5

Review Paper

Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044

Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6)595-608

Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7)560-574

Book Chapter

Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 3779-100

Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31

By |2019-08-02T18:54:51+00:00September 5th, 2018|Categories: Friday Lectures, Molecular Biology, Neurobiology, Neuroscience, Recommended Readings|Tags: , , , , |Comments Off on Recommended Readings: John Hardy, Ph.D. Friday September 7, 2018

About the Author:

Ilaria Ceglia, Ph.D., Science Informationist - Ilaria joined the Markus Library Team in 2017. As science liaison between the Rockefeller scientific community and the library, Ilaria assists Rockefeller scientists find, and effectively use, the scholarly communication tools available at the library, provides customized literature searching, delivers research information reports and publications metric analysis to enhance collaborations between Rockefeller and leading scientific institutions, provides access to digital content to manage large data freely accessible. Ilaria manages a drug development database to perform clinical literature searches and drugs pipeline reports for Rockefeller research faculty, scientists and clinicians. As the NIH compliance monitor for the Rockefeller University, Ilaria helps faculty to solve scientific submission requirements issues and ensures Rockefeller remains compliant with NIH Public Access Policy. Her role also includes evaluate and select new databases to complement other resource center services, organize tutorial training sessions in areas of life sciences and on the use of reference management platforms F1000 Workspace, Scopus, Web of Science and PubMed literature searching, managing recommendation readings library blog for lectures and special seminars. Ilaria is a neuroscientist and a former Rockefeller postdoctoral and research associate of Dr. Paul Greengard’s laboratory. She was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai, New York and an Adjunct Assistant Professor at City College and Hunter College in New York, where she taught Cell Biology and Biochemistry. As an Italian expat living in New York, Ilaria is an enthusiastic proponent of Italian culture among friends and colleagues.