Webinar Friday Lecture Series
(open to the Rockefeller community)
Friday, May 13, 2022
Peter Walter, Ph.D.SVP & Institute Director,
Altos Labs – Bay Area Institute of Science
Distinguished Professor Emeritus,
Department of Biochemistry & Biophysics
University of California, San Francisco
Targeting the Cell’s Stress Pathways for Therapeutic Benefit
Recommended Readings:
Empirical Articles
Le Thomas, A., Ferri, E., Marsters, S., Harnoss, J. M., Lawrence, D. A., Zuazo-Gaztelu, I., Modrusan, Z., Chan, S., Solon, M., Chalouni, C., Li, W., Koeppen, H., Rudolph, J., Wang, W., Wu, T. D., Walter, P., & Ashkenazi, A. (2021). Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α. Nature communications, 12(1), 7310.
Schoof, M., Wang, L., Cogan, J. Z., Lawrence, R. E., Boone, M., Wuerth, J. D., Frost, A., & Walter, P. (2021). Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nature communications, 12(1), 7103.
Tran, N. H., Carter, S. D., De Mazière, A., Ashkenazi, A., Klumperman, J., Walter, P., & Jensen, G. J. (2021). The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes. Science (New York, N.Y.), 374(6563), 52–57
Li, W., Crotty, K., Garrido Ruiz, D., Voorhies, M., Rivera, C., Sil, A., Mullins, R. D., Jacobson, M. P., Peschek, J., & Walter, P. (2021). Protomer alignment modulates specificity of RNA substrate recognition by Ire1. eLife, 10, e67425.
Schoof, M., Boone, M., Wang, L., Lawrence, R., Frost, A., & Walter, P. (2021). eIF2B conformation and assembly state regulate the integrated stress response. eLife, 10, e65703.
