Friday Lecture Series
(open to the Rockefeller community)
Friday, May 20, 2022
John O’Shea, Jr., M.D.
Senior Investigator, LCBS-MIIB
Chief, Molecular Immunology and Inflammation Branch
Scientific Director,
NIAMS,
NIH
Cytokine Signaling: A Paradigm, Translation, and So Many Questions Ahead
Recommended Readings:
Empirical Articles
Cannons, J. L., Villarino, A. V., Kapnick, S. M., Preite, S., Shih, H. Y., Gomez-Rodriguez, J., Kaul, Z., Shibata, H., Reilley, J. M., Huang, B., Handon, R., McBain, I. T., Gossa, S., Wu, T., Su, H. C., McGavern, D. B., O’Shea, J. J., McGuire, P. J., Uzel, G., & Schwartzberg, P. L. (2021). PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory. Cell reports, 37(2), 109804.
Takahashi, H., Nomura, H., Iriki, H., Kubo, A., Isami, K., Mikami, Y., Mukai, M., Sasaki, T., Yamagami, J., Kudoh, J., Ito, H., Kamata, A., Kurebayashi, Y., Yoshida, H., Yoshimura, A., Sun, H. W., Suematsu, M., O’Shea, J. J., Kanno, Y., & Amagai, M. (2021). Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin. Science immunology, 6(64), eabb6444.
Mikami, Y., Philips, R. L., Sciumè, G., Petermann, F., Meylan, F., Nagashima, H., Yao, C., Davis, F. P., Brooks, S. R., Sun, H. W., Takahashi, H., Poholek, A. C., Shih, H. Y., Afzali, B., Muljo, S. A., Hafner, M., Kanno, Y., & O’Shea, J. J. (2021). MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23. Immunity, 54(3), 514–525.e6.
Yao, C., Lou, G., Sun, H. W., Zhu, Z., Sun, Y., Chen, Z., Chauss, D., Moseman, E. A., Cheng, J., D’Antonio, M. A., Shi, W., Shi, J., Kometani, K., Kurosaki, T., Wherry, E. J., Afzali, B., Gattinoni, L., Zhu, Y., McGavern, D. B., O’Shea, J. J., Schwartzberg P.L., & Wu, T. (2021). BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells. Nature immunology, 22(3), 370–380.
Wiedemann, G. M., Grassmann, S., Lau, C. M., Rapp, M., Villarino, A. V., Friedrich, C., Gasteiger, G., O’Shea, J. J., & Sun, J. C. (2020). Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells. Cell reports, 33(11), 108498.
Reviews
Luo, Y., Alexander, M., Gadina, M., O’Shea, J. J., Meylan, F., & Schwartz, D. M. (2021). JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition. The Journal of allergy and clinical immunology, 148(4), 911–925.
Morrison, T. A., Hudson, W. H., Chisolm, D. A., Kanno, Y., Shih, H. Y., Ahmed, R., Henao-Mejia, J., Hafner, M., & O’Shea, J. J. (2022). Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory. Cold Spring Harbor perspectives in biology, 14(1), a037952.
