Webinar Monday Lecture Series
(open to the Rockefeller community)
Monday, February 28, 2022
Jean-Laurent Casanova, M.D., Ph.D.
Professor
Head of the Laboratory of Human Genetics of Infectious Diseases,
Necker Branch, Imagine Institute, INSERM and University of Paris
Pediatrician, Necker Hospital for Sick Children
Levy Family Professor
Head of Laboratory of the St. Giles Laboratory of Human Genetics of Infectious Diseases
Senior Attending Physician, Rockefeller University Hospital
Investigator, Howard Hughes Medical Institute
Rockefeller University
Human Genetic and Immunological Determinants of Critical COVID-19 Pneumonia
Recommended Readings:
Empirical Articles
Chen, J., Jing, H., Martin-Nalda, A., Bastard, P., Rivière, J. G., Liu, Z., Colobran, R., Lee, D., Tung, W., Manry, J., Hasek, M., Boucherit, S., Lorenzo, L., Rozenberg, F., Aubart, M., Abel, L., Su, H. C., Soler Palacin, P., Casanova, J. L., & Zhang, S. Y. (2021). Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis. The Journal of experimental medicine, 218(12), e20211349.
Lévy, R., Zhang, P., Bastard, P., Dorgham, K., Melki, I., Hadchouel, A., Hartoularos, G. C., Neven, B., Castelle, M., Roy, C., Toin, T., Berteloot, L., Bizien, L., Abid, H., Burgard, M., Houhou-Fidouh, N., Rozenberg, F., Jouanguy, E., Ye, C. J., Gorochov, G., … Casanova, J. L. (2021). Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child. Proceedings of the National Academy of Sciences of the United States of America, 118(45), e2114390118.
Carapito, R., Li, R., Helms, J., Carapito, C., Gujja, S., Rolli, V., Guimaraes, R., Malagon-Lopez, J., Spinnhirny, P., Lederle, A., Mohseninia, R., Hirschler, A., Muller, L., Bastard, P., Gervais, A., Zhang, Q., Danion, F., Ruch, Y., Schenck, M., Collange, O., … Bahram, S. (2022). Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort. Science translational medicine, 14(628), eabj7521.
Asano, T., Boisson, B., Onodi, F., Matuozzo, D., Moncada-Velez, M., Maglorius Renkilaraj, M., Zhang, P., Meertens, L., Bolze, A., Materna, M., Korniotis, S., Gervais, A., Talouarn, E., Bigio, B., Seeleuthner, Y., Bilguvar, K., Zhang, Y., Neehus, A. L., Ogishi, M., Pelham, S. J., … Casanova, J. L. (2021). X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19. Science immunology, 6(62), eabl4348.
Bastard, P., Gervais, A., Le Voyer, T., Rosain, J., Philippot, Q., Manry, J., Michailidis, E., Hoffmann, H. H., Eto, S., Garcia-Prat, M., Bizien, L., Parra-Martínez, A., Yang, R., Haljasmägi, L., Migaud, M., Särekannu, K., Maslovskaja, J., de Prost, N., Tandjaoui-Lambiotte, Y., Luyt, C. E., … Casanova, J. L. (2021). Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths. Science immunology, 6(62), eabl4340.
van der Wijst, M., Vazquez, S. E., Hartoularos, G. C., Bastard, P., Grant, T., Bueno, R., Lee, D. S., Greenland, J. R., Sun, Y., Perez, R., Ogorodnikov, A., Ward, A., Mann, S. A., Lynch, K. L., Yun, C., Havlir, D. V., Chamie, G., Marquez, C., Greenhouse, B., Lionakis, M. S., … Ye, C. J. (2021). Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv : the preprint server for biology, 2021.03.09.434529.
Lopez, J., Mommert, M., Mouton, W., Pizzorno, A., Brengel-Pesce, K., Mezidi, M., Villard, M., Lina, B., Richard, J. C., Fassier, J. B., Cheynet, V., Padey, B., Duliere, V., Julien, T., Paul, S., Bastard, P., Belot, A., Bal, A., Casanova, J. L., Rosa-Calatrava, M., … Trouillet-Assant, S. (2021). Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs. The Journal of experimental medicine, 218(10), e20211211.
