Friday Lecture Series
(open to the Rockefeller community)
Friday, February 25, 2022
Michel C. Nussenzweig, M.D., Ph.D.
Zanvil A. Cohn and Ralph M. Steinman Professor,
Head of the Laboratory of Molecular Immunology,
Director of the Christopher Browne Center for Immunology and Immune Diseases
Senior Physician, Rockefeller University Hospital
Investigator, Howard Hughes Medical Institute
Rockefeller University
Humoral Immune Responses to Viral Infections and Vaccines in Mice and Humans
Recommended Readings:
Empirical Articles
Escolano, A., Gristick, H. B., Gautam, R., DeLaitsch, A. T., Abernathy, M. E., Yang, Z., Wang, H., Hoffmann, M., Nishimura, Y., Wang, Z., Koranda, N., Kakutani, L. M., Gao, H., Gnanapragasam, P., Raina, H., Gazumyan, A., Cipolla, M., Oliveira, T. Y., Ramos, V., Irvine, D. J., … Bjorkman, P. J. (2021). Sequential immunization of macaques elicits heterologous neutralizing antibodies targeting the V3-glycan patch of HIV-1 Env. Science translational medicine, 13(621), eabk1533.
Abernathy, M. E., Gristick, H. B., Vielmetter, J., Keeffe, J. R., Gnanapragasam, P., Lee, Y. E., Escolano, A., Gautam, R., Seaman, M. S., Martin, M. A., Nussenzweig, M. C., & Bjorkman, P. J. (2021). Antibody elicited by HIV-1 immunogen vaccination in macaques displaces Env fusion peptide and destroys a neutralizing epitope. NPJ vaccines, 6(1), 126.
Cho, A., Muecksch, F., Schaefer-Babajew, D., Wang, Z., Finkin, S., Gaebler, C., Ramos, V., Cipolla, M., Mendoza, P., Agudelo, M., Bednarski, E., DaSilva, J., Shimeliovich, I., Dizon, J., Daga, M., Millard, K. G., Turroja, M., Schmidt, F., Zhang, F., Tanfous, T. B., … Nussenzweig, M. C. (2021). Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination. Nature, 600(7889), 517–522.
Muecksch, F., Weisblum, Y., Barnes, C. O., Schmidt, F., Schaefer-Babajew, D., Wang, Z., C Lorenzi, J. C., Flyak, A. I., DeLaitsch, A. T., Huey-Tubman, K. E., Hou, S., Schiffer, C. A., Gaebler, C., Da Silva, J., Poston, D., Finkin, S., Cho, A., Cipolla, M., Oliveira, T. Y., Millard, K. G., … Bieniasz, P. D. (2021). Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations. Immunity, 54(8), 1853–1868.e7.
Viant, C., Wirthmiller, T., ElTanbouly, M. A., Chen, S. T., Cipolla, M., Ramos, V., Oliveira, T. Y., Stamatatos, L., & Nussenzweig, M. C. (2021). Germinal center-dependent and -independent memory B cells produced throughout the immune response. The Journal of experimental medicine, 218(8), e20202489.
Viant, C., Escolano, A., Chen, S. T., & Nussenzweig, M. C. (2021). Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells. STAR protocols, 2(2), 100389.
