Monday Lectures
Monday, December 16, 2019 4:00 p.m.
Carson Family Auditorium
Agata Smogorzewska, M.D., Ph.D.
Associate Professor and Head
Laboratory of Genome Maintenance
The Rockefeller University
Stress Response at the Replication Fork
Recommended Readings:
Empirical Articles
Rickman, K.A., Noonan, R., Lach, F.P., Sridhar, S., Wang, A.T., Abhyankar, A., Kelly, M., Auerbach, A.D., and Smogorzewska, A. (2019). Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand crosslinks. bioRxiv, 811968
Kottemann, Molly C.; Conti, Brooke A.; Lach, Francis P.; et al. (2018). Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity. MOLECULAR CELL. 69 (1): 24-35.e5
Thongthip S, Conti BA, Lach FP, Smogorzewska A. (2017). Suppression of non-homologous end joining does not rescue DNA repair defects in Fanconi anemia patient cells. bioRxiv 151472
Wang, Anderson T.; Kim, Taeho; Wagner, John E.; et al. (2015). A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. MOLECULAR CELL. 59 (3): 478-490
Joo, Woo; Xu, Guozhou; Persky, Nicole S.; et al. (2011). Structure of the FANCI-FANCD2 Complex: Insights into the Fanconi Anemia DNA Repair Pathway. SCIENCE. 333 (6040): 312-316
Kim, Yonghwan; Lach, Francis P.; Desetty, Rohini; et al. (2011). Mutations of the SLX4 gene in Fanconi anemia. NATURE GENETICS. 43 (2): 142-U91
Svendsen, Jennifer M.; Smogorzewska, Agata; Sowa, Mathew E.; et al. (2009). Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair. CELL. 138 (1): 63-77
Ishiai, Masamichi; Kitao, Hiroyuki; Smogorzewska, Agata; et al. (2008). FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 15 (11): 1138-1146
Review Papers
Rickman, Kimberly; Smogorzewska, Agata. (2019). Advances in understanding DNA processing and protection at stalled replication forks. JOURNAL OF CELL BIOLOGY. 218 (4): 1096-1107
Kottemann, Molly C.; Smogorzewska, Agata. (2013). Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. NATURE. 493 (7432): 356-363