Recommended Readings: Kevan Shokat, Ph.D., Friday September 17, 2021

Recommended Readings: Kevan Shokat, Ph.D., Friday September 17, 2021

Webinar Friday Lecture SeriesKevan Shokat, Ph.D.

(open to the Tri-I community)

Friday, September 17, 2021

Kevan Shokat, Ph.D.


Department of Cellular and Molecular Pharmacology and Pharmaceutical Chemistry

University of California, San Francisco

Discovering and Deploying Chemical Strategies to Drug KRAS: The Formerly Undruggable Oncogene

Recommended Readings:

Empirical Articles

Nnadi, Chimno I.; Jenkins, Meredith L.; Gentile, Daniel R. et al. (2018). Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 58(2): 464-471

Gentile, Daniel R.; Rathinaswamy, Manoj K.; Jenkins, Meredith L. et al. (2017). Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. CELL CHEMICAL BIOLOGY. 24(12): 1455 -1466.e14

Novotny, Chris J.; Hamilton, Gregory L.; McCormick, Frank; Shokat, Kevan M. (2017). Farnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras. ACS CHEMICAL BIOLOGY. 12(7): 1956-1962

McGregor, Lynn M.; Jenkins, Meredith L.; Kerwin, Caitlin et al. (2017). Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. BIOCHEMISTRY. 56 (25): 3178-3183

Review Paper

Dang, CV; Reddy, EP; Shokat, KM and et. (2017). Drugging the ‘undruggable’ cancer targets. NATURE REVIEWS CANCER. 17(8): 502-508

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About the Author:

Ilaria Ceglia, Ph.D., Science Informationist - Ilaria joined the Markus Library Team in 2017. As science liaison between the Rockefeller scientific community and the library, Ilaria assists Rockefeller scientists find, and effectively use, the scholarly communication tools available at the library, provides customized literature searching, delivers research information reports and publications metric analysis to enhance collaborations between Rockefeller and leading scientific institutions, provides access to digital content to manage large data freely accessible. Ilaria manages a drug development database to perform clinical literature searches and drugs pipeline reports for Rockefeller research faculty, scientists and clinicians. As the NIH compliance monitor for the Rockefeller University, Ilaria helps faculty to solve scientific submission requirements issues and ensures Rockefeller remains compliant with NIH Public Access Policy. Her role also includes evaluate and select new databases to complement other resource center services, organize tutorial training sessions in areas of life sciences and on the use of reference management platforms F1000 Workspace, Scopus, Web of Science and PubMed literature searching, managing recommendation readings library blog for lectures and special seminars. Ilaria is a neuroscientist and a former Rockefeller postdoctoral and research associate of Dr. Paul Greengard’s laboratory. She was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai, New York and an Adjunct Assistant Professor at City College and Hunter College in New York, where she taught Cell Biology and Biochemistry. As an Italian expat living in New York, Ilaria is an enthusiastic proponent of Italian culture among friends and colleagues.