Webinar Friday Lecture Series
(open to the Tri-I community)
Friday, February 5, 2021
Job Dekker, Ph.D.
Joseph J. Byrne Chair, Professor and Co-director
Department of Biochemistry and Molecular Pharmacology
University of Massachusetts Medical School
Mechanisms of Chromosome Folding
Recommended Readings:
Empirical Articles
Fitz-James, Maximilian H.; Tong, Pin; Pidoux, Alison L.; et al. (2020). Large domains of heterochromatin direct the formation of short mitotic chromosome loops. ELIFE. 9
Abramo, Kristin; Valton, Anne-Laure; Venev, Sergey V.; et al. (2019). A chromosome folding intermediate at the condensin-to-cohesin transition during telophase. NATURE CELL BIOLOGY. 21 (11): 1393-
Gibcus, Johan H.; Samejima, Kumiko; Goloborodko, Anton; et al. (2018). A pathway for mitotic chromosome formation. SCIENCE. 359 (6376): 652-
Schalbetter, Stephanie Andrea; Goloborodko, Anton; Fudenberg, Geoffrey; et al. (2017). SMC complexes differentially compact mitotic chromosomes according to genomic context. NATURE CELL BIOLOGY. 19 (9): 1071-
Crane, Emily; Bian, Qian; McCord, Rachel Patton; et al. (2015). Condensin-driven remodelling of X chromosome topology during dosage compensation. NATURE. 523 (7559): 240-U299
Review Papers
Oomen, Marlies E.; Dekker, Job. (2017). Epigenetic characteristics of the mitotic chromosome in 1D and 3D. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 52 (2): 185-204
Dekker, Job; Heard, Edith. (2015). Structural and functional diversity of Topologically Associating Domains. FEBS LETTERS. 589 (20): 2877-2884
Dekker, Job. (2014). Two ways to fold the genome during the cell cycle: insights obtained with chromosome conformation capture. EPIGENETICS & CHROMATIN. 7