Friday Lectures
Friday, March 13, 2020 3:45 p.m.
Caspary Auditorium
Ramanujan Hegde, Ph.D.
Group Leader
Laboratory of Molecular Biology
MRC – University of Cambridge, UK
Mechanisms of Multi-pass Membrane Protein Biogenesis
Recommended Readings:
Empirical Articles
Volkmar, Norbert; Thezenas, Maria-Laetitia; Louie, Sharon M.; et al. (2019). The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis. JOURNAL OF CELL SCIENCE. 132 (2)
Zavodszky, E. and Hegde, R. S. (2019). Misfolded GPI-anchored proteins are escorted throughthe secretory pathway by ER-derived factors. Elife
Chitwood, Patrick J.; Juszkiewicz, Szymon; Guna, Alina; et al. (2018). EMC Is Required to Initiate Accurate Membrane Protein Topogenesis. CELL. 175 (6): 1507-+
Chen, Changchun; Itakura, Eisuke; Weber, Katherine P.; et al. (2014). An ER Complex of ODR-4 and ODR-8/Ufm1 Specific Protease 2 Promotes GPCR Maturation by a Ufm1-Independent Mechanism. PLOS GENETICS. 10 (3)
Satpute-Krishnan, Prasanna; Ajinkya, Monica; Bhat, Savithri; et al. (2014). ER Stress-Induced Clearance of Misfolded GPI-Anchored Proteins via the Secretory Pathway. CELL. 158 (3): 522-533
Hessa, Tara; Sharma, Ajay; Mariappan, Malaiyalam; et al. (2011). Protein targeting and degradation are coupled for elimination of mislocalized proteins. NATURE. 475 (7356): 394-U154
Review Papers
Guna, Alina; Hegde, Ramanujan S. (2018). Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control. CURRENT BIOLOGY. 28 (8): R498-R511
Hegde, Ramanujan S.; Keenan, Robert J. (2011). Tail-anchored membrane protein insertion into the endoplasmic reticulum. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 12 (12): 787-798
Ilaria Ceglia, Ph.D., Science Informationist -
Ilaria joined the Markus Library Team in 2017. As science liaison
between the Rockefeller scientific community and the library, Ilaria
assists Rockefeller scientists find, and effectively use, the scholarly
communication tools available at the library, provides customized
literature searching, delivers research information reports and
publications metric analysis to enhance collaborations between
Rockefeller and leading scientific institutions, provides access to digital
content to manage large data freely accessible. Ilaria manages a drug
development database to perform clinical literature searches and drugs
pipeline reports for Rockefeller research faculty, scientists and clinicians.
As the NIH compliance monitor for the Rockefeller University, Ilaria
helps faculty to solve scientific submission requirements issues and ensures Rockefeller remains
compliant with NIH Public Access Policy. Her role also includes evaluate and select new databases to
complement other resource center services, organize tutorial training sessions in areas of life sciences
and on the use of reference management platforms F1000 Workspace, Scopus, Web of Science and
PubMed literature searching, managing recommendation readings library blog for lectures and special
seminars.
Ilaria is a neuroscientist and a former Rockefeller postdoctoral and research associate of Dr. Paul
Greengard’s laboratory. She was a Research Assistant Professor at the Icahn School of Medicine at
Mount Sinai, New York and an Adjunct Assistant Professor at City College and Hunter College in New
York, where she taught Cell Biology and Biochemistry.
As an Italian expat living in New York, Ilaria is an enthusiastic proponent of Italian culture among friends
and colleagues.