Monday Lectures
Monday, May 20, 2019 4:00 p.m.
Carson Family Auditorium
Kivanç Birsoy, Ph.D.
Chapman Perelman Assistant Professor and Head
Laboratory of Metabolic Regulation and Genetics
The Rockefeller University
Metabolic Limitations of Cancer Cell Proliferation
Recommended Readings:
Science News
Oxygen-Starved Cancer Cells Languish without Aspartate. Jun 25, 2018. Genetic Engineering & Biotechnology News
Empirical Articles
Garcia-Bermudez, Javier; Baudrier, Lou; Bayraktar, Erol Can; et al. (2019). Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. NATURE. 567 (7746): 118-+
Phillips, Richard E.; Yang, Yanhong; Smith, Ryan C.; et al. (2019). Target identification reveals lanosterol synthase as a vulnerability in glioma. PNAS. 116 (16): 7957-7962
Bayraktar, Erol C.; Baudrier, Lou; Ozerdem, Ceren; et al. (2019). MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. PNAS. 116 (1) : 303-312
Garcia-Bermudez, Javier; Baudrier, Lou; La, Konnor; et al. (2018). Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. NATURE CELL BIOLOGY. 20 (7): 775-+
Peng, Xinxin; Chen, Zhongyuan; Farshidfar, Farshad; et al. (2018). Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. CELL REPORTS. 23 (1): 255-+
Reczek, Colleen R.; Birsoy, Kivanc; Kong, Hyewon; et al. (2017). A CRISPR screen identifies a pathway required for paraquat-induced cell death. NATURE CHEMICAL BIOLOGY. 13 (12): 1274-+
Chen, Walter W.; Freinkman, Elizaveta; Wang, Tim; et al. (2016). Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. CELL. 166 (5): 1324-+