Recommended Readings: Timothy Ryan, Ph.D., Monday October 23th, 2017

Monday Lectures

Monday, October 23, 2017  3:45 p.m.

Carson Family Auditorium

Timothy Ryan, Ph.D.

Tri-Institutional Professor

Department of biochemistry

Weill Cornell Medical College

The Cost of Thinking: Metabolic Fitness at the Synapse Level

Recommended Readings:

Jaime de Juan Sanz (2017). The surprising metabolism of “exercising” neurons. Plos Blogs

http://news.cornell.edu/stories/2017/01/brain-cells-mobilize-sugar-response-increased-activity

Ashrafi, Ghazaleh; Ryan, Timothy A. (2017). Glucose metabolism in nerve terminals. CURRENT OPINION IN NEUROBIOLOGY. 45:156-161

Ashrafi, Ghazaleh; Wu, Zhuhao; Farrell, Ryan J.; et al. (2017). GLUT4 Mobilization Supports Energetic Demands of Active Synapses. NEURON. 93 (3): 606-+

Jang, SoRi; Nelson, Jessica C.; Bend, Eric G.; et al. (2016). Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function. NEURON. 90 (2): 278-291

Magistretti, Pierre J.; Allaman, Igor (2015). A Cellular Perspective on Brain Energy Metabolism and Functional Imaging. NEURON. 86 (4): 883-901

Rangaraju, Vidhya; Calloway, Nathaniel; Ryan, Timothy A.(2014). Activity-Driven Local ATP Synthesis Is Required for Synaptic Function. CELL. 156 (4): 825-835

Recommended Readings: Sean F. Brady, Ph.D., Friday October 27th, 2017

Friday Lectures

Friday, October 27, 2017  3:45 p.m.

Caspary Auditorium

Sean F. Brady, Ph.D.

Evnin Associate Professor and Head

Laboratory of Genetically Encoded Small Molecules

The Rockefeller University

Watch your step, there is new chemistry everywhere

Recommended Readings:

Cohen LJ, Han S, Huang YH, Brady SF. (2017). Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library.  ACS Infect Dis.  In Press doi: 10.1021/acsinfecdis.7b00081

Fierer, Noah (2017). Embracing the unknown: disentangling the complexities of the soil microbiome. NATURE REVIEWS MICROBIOLOGY. 15 (10): 579-590

Chu, John; Vila-Farres, Xavier; Inoyama, Daigo; et al. (2016). Discovery of MRSA active antibiotics using primary sequence from the human microbiome.  NATURE CHEMICAL BIOLOGY. 12 (12): 1004-+

O’Brien, Sarah L.; Gibbons, Sean M.; Owens, Sarah M.; et al. (2016). Spatial scale drives patterns in soil bacterial diversity.  ENVIRONMENTAL MICROBIOLOGY. 18 (6): 2039-2051

Medema, Marnix H.; Kottmann, Renzo; Yilmaz, Pelin; et al. (2015). Minimum Information about a Biosynthetic Gene cluster. NATURE CHEMICAL BIOLOGY. (11) 9: 625-631

Owen, Jeremy G.; Reddy, Boojala Vijay B.; Ternei, Melinda A.; et al. (2013). Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. PNAS. 110 (29): 11797-11802  

 

Recommended Readings: Luciano Marraffini, Ph.D., Friday October 20th, 2017

Friday Lectures

Friday, October 20, 2017  3:45 p.m.

Caspary Auditorium

Luciano Marraffini, Ph.D.

Associate Professor and Head

Laboratory of Bacteriology

The Rockefeller University

CRISPR-Cas, Acquired Immunity in Prokaryotes

 

Recommended Readings:

Niewoehner, Ole; Garcia-Doval, Carmela; Rostol, Jakob T.; et al. (2017). Type III CRISPR-Cas systems produce cyclic oligoadenylate second messengers.  NATURE. 548 (7669): 543-+

Modell, Joshua W.; Jiang, Wenyan; Marraffini, Luciano A. (2017). CRISPR-Cas systems exploit viral DNA injection to establish and maintain adaptive immunity. NATURE. 544 (7648): 101-+  

Marraffini, Luciano A. (2017). Sensing danger. PNAS. 114 (1): 15-16

Heler, Robert; Wright, Addison V.; Vucelja, Marija; et al. (2017). Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. MOLECULAR CELL. 65 (1): 168-175

Marraffini, Luciano A. (2015). CRISPR-Cas immunity in prokaryotes. NATURE. 526 (7571): 55-61

McGinn, Jon; Marraffini, Luciano A. (2016). CRISPR-Cas Systems Optimize Their Immune Response by Specifying the Site of Spacer Integration. MOLECULAR CELL. 64 (3): 616-623

Barrangou, Rodolphe; Marraffini, Luciano A. (2014). CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity. MOLECULAR CELL. 54 (2): 234-244

Cong, Le; Ran, F. Ann; Cox, David; et al. (2013). Multiplex Genome Engineering Using CRISPR/Cas Systems.  SCIENCE. 339 (6121): 819-823

 

 

Recommended Readings: Anja Groth, Ph.D., Friday October 13th, 2017

Friday Lectures

Friday, October 13, 2017  3:45 p.m.

Caspary Auditorium

Anja Groth, Ph.D.

Professor and Group Leader

Biotech Research and Innovation Centre (BRIC)

 University of Copenhagen

Chromatin Replication and Epigenome Maintenance

 

Recommended Readings:

Hammond, Colin M.; Stromme, Caroline B.; Huang, Hongda; et al. (2017). Histone chaperone networks shaping chromatin function. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 18 (3): 141-158

Saredi, Giulia; Huang, Hongda; Hammond, Colin M.; et al. (2016). H4K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. NATURE. 534 (7609): 714-+   

Alabert, Constance; Barth, Teresa K.; Reveron-Gomez, Nazaret; et al. (2015). Two distinct modes for propagation of histone PTMs across the cell cycle. GENES & DEVELOPMENT 29 (6): 585-590

Huang, Hongda; Stromme, Caroline B.; Saredi, Giulia; et al. (2015). A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 22 (8): 618-626

Alabert, Constance; Bukowski-Wills, Jimi-Carlo; Lee, Sung-Bau; et al. (2014). Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.  NATURE CELL BIOLOGY. 16 (3): 281-+

Alabert, Constance; Groth, Anja (2012). Chromatin replication and epigenome maintenance. NATURE REVIEWS MOLECULAR CELL BIOLOGY. 13 (3): 153-167

 

 

Recommended Readings: Tom Maniatis, Ph.D., Friday October 6th, 2017

Friday Lectures

Friday, October 06, 2017  3:45 p.m.

Caspary Auditorium

Tom Maniatis, Ph.D.

Isidore S. Edelman Professor and Chair

Department of Biochemistry and Molecular Biophysics

Columbia University Medical Center

The Generation and Function of Protocadherin Cell Surface Diversity in Mammalian Neural Circuit Assembly

Recommended Readings:

Technology Networks Wrong Wiring Causes Depression. Apr 28, 2017

Rubinstein, Rotem; Goodman, Kerry Marie; Maniatis, Tom; et al. (2017). Structural origins of clustered protocadherin-mediated neuronal barcoding. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 69 (SI): 140-150. PLEASE REQUEST FROM MARKUS LIBRARY.

Chen, Weisheng V.; Nwakeze, Chiamaka L.; Denny, Christine A.; et al. (2017). Pcdh alpha c2 is required for axonal tiling and assembly of serotonergic circuitries in mice. SCIENCE. 356 (6336): 406-410

Mountoufaris, George; Chen, Weisheng V.; Hirabayashi, Yusuke; et al. (2017). Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. SCIENCE. 356 (6336): 411-413  

Goodman, Kerry Marie; Rubinstein, Rotem; Thu, Chan Aye; et al. (2016). gamma-Protocadherin structural diversity and functional implications. ELIFE. 5: e20930  

Chen, Weisheng V.; Maniatis, Tom (2013). Clustered protocadherins. DEVELOPMENT. 140 (16): 3297-3302

Lefebvre, Julie L.; Kostadinov, Dimitar; Chen, Weisheng V.; et al. (2012). Protocadherins mediate dendritic self-avoidance in the mammalian nervous system. NATURE. 488 (7412): 517-+


Recommended Readings: Nancy A. Moran, Ph.D., Friday September 22th, 2017

Friday Lectures

Friday, September 22, 2017  3:45 p.m.

Caspary Auditorium

Nancy A. Moran, Ph.D.

Leslie Surginer Endowed Professor

Department of Integrative Biology

University of Texas

The evolution and function of gut communities in social bees

Recommended Readings:

Ashley P. Taylor. March 29, 2017. In Certain Social Bees, Gut Microbiomes Follow Phylogeny. TheScientist

Kwong, Waldan K.; Moran, Nancy A. (2017). Gut microbial communities of social bees. NATURE REVIEWS MICROBIOLOGY. 14 (6): 374-384

Kwong, Waldan K; Medina, Luis A; Koch, Hauke; et al. (2017). Dynamic microbiome evolution in social bees. SCIENCE ADVANCES. 3 (3): e1600513

Powell, Elijah; Ratnayeke, Nalin; Moran, Nancy A. (2016). Strain diversity and host specificity in a specialized gut symbiont of honeybees and bumblebees. MOLECULAR ECOLOGY. 25 (18): 4461-4471

Engel, Philipp; Moran, Nancy A. (2013). The gut microbiota of insects – diversity in structure and function. FEMS MICROBIOLOGY REVIEW. 37 (5): 699-735

Schloissnig, Siegfried; Arumugam, Manimozhiyan; Sunagawa, Shinichi; et al. (2013). Genomic variation landscape of the human gut microbiome. NATURE. 493 (7430): 45-50

Tian, Baoyu; Fadhil, Nibal H.; Powell, J. Elijah; et al. (2012). Long-Term Exposure to Antibiotics Has Caused Accumulation of Resistance Determinants in the Gut Microbiota of Honeybees. MBIO. 3 (6): e00377-12


 

Recommended Readings: Erika Pearce, Ph.D., Wednesday September 20th, 2017

Special Seminar Series

Wednesday, September 20, 2017  4:00 p.m.

Carson Family Auditorium

Erika Pearce, Ph.D.

Senior Group Leader and Director

Department of Immunometabolism

Max Planck Institute of Immunobiology and Epigenetics

Mitochondrial Shapeshifting in the T Cell Response

Recommended Readings:

Erika Pearce. (2017). The Influence of Metabolism on the Function of T Cell Types. Latest Thinking.

Pan, Youdong; Tian, Tian; Park, Chang Ook; et al. (2017). Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. NATURE. 543 (7644): 252-+  

Man, Kevin; Kutyavin, Vassily I.; Chawla, Ajay. (2017). Tissue immunometabolism: development, physiology, and pathobiology. CELL METABOLISM. 25 (1): 11-26

Buck, Michael D.; O’Sullivan, David; Geltink, Ramon I. Klein; et al. (2016). Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. CELL. 66 (1): 63-76

Liesa, Marc; Shirihai, Orian S. (2016). Mitochondrial Networking in T Cell Memory. CELL. 166 (1): 9-10

Peng, Min; Yin, Na; Chhangawala, Sagar; et al. (2016). Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. SCIENCE. 354 (6311): 481-484

Newton, Ryan; Priyadharshini, Bhavana; Turka, Laurence A. (2016). Immunometabolism of regulatory T cells. NATURE IMMUNOLOGY. 17 (6): 618-625

Jang, Kyoung-Jin; Mano, Hiroto; Aoki, Koji; et al. (2015). Mitochondrial function provides instructive signals for activation-induced B-cell fates. NATURE COMMUNICATIONS. 6: 6750

Pearce, Erika L.; Pearce, Edward J. (2013). Metabolic Pathways in Immune Cell Activation and Quiescence. IMMUNITY. 38 (4): 633-643 

 

Recommended Readings: Daniel Kronauer, Ph.D., Friday September 15th, 2017

Friday Lectures

Friday, September 15, 2017  3:45 p.m.

Caspary Auditorium

Daniel Kronauer, Ph.D.

Stanley S. and Sydney R. Shuman Assistant Professor and Head

Laboratory of Social Evolution and Behavior

The Rockefeller University

Communication and Social Behavior in Ants

Recommended Readings:

News provided by NYU Langone Health (2017). Mutant Ants provide insights into social interaction.

Trible, Waring; Olivos-Cisneros, Leonora; McKenzie, Sean K.; et al. (2017). orco Mutagenesis Causes Loss of Antennal Lobe Glomeruli and Impaired Social Behavior in Ants. CELL. 170 (4): 727-+  

McKenzie, Sean K.; Fetter-Pruneda, Ingrid; Ruta, Vanessa; et al. (2016). Transcriptomics and neuroanatomy of the clonal raider ant implicate an expanded clade of odorant receptors in chemical communication. PNAS. 113 (49): 14091-14096

Leonhardt, Sara Diana; Menzel, Florian; Nehring, Volker; et al. (2016). Ecology and Evolution of Communication in Social Insects. CELL. 164 (6): 1277-1287

Oxley, Peter R.; Ji, Lu; Fetter-Pruneda, Ingrid; et al. (2014). The Genome of the Clonal Raider Ant Cerapachys biroi. CURRENT BIOLOGY. 24 (4): 451-458  

Sumner, Seirian (2014). The importance of genomic novelty in social evolution. MOLECULAR ECOLOGY. 23 (1): 26-28

 

Recommended Readings: Kenneth Zaret, Ph.D., Friday May 26th, 2017

Friday Lectures

Friday, May 26, 2017  3:45 p.m.

Caspary Auditorium

Kenneth Zaret, Ph.D.

Joseph Leidy Professor, Department of Cell and Developmental Biology

Director, Institute for Regenerative Medicine

Perelman School of Medicine, University of Pennsylvania

Overcoming Chromatin Barriers to Control Cell Fate

Recommended Readings:

Zaret, Kenneth S.; Lerner, Jonathan; Iwafuchi-Doi, Makiko (2016). Chromatin Scanning by Dynamic Binding of Pioneer Factors. MOLECULAR CELL. 62 (5): 665-667

Zaret, Kenneth S.; Mango, Susan E. (2016). Pioneer transcription factors, chromatin dynamics, and cell fate control. CURRENT OPINION IN GENETICS & DEVELOPMENT. 37: 76-81

Iwafuchi-Doi, Makiko; Donahue, Greg; Kakumanu, Akshay; et al. (2016). The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. MOLECULAR CELL. 62(1): 79-91

Soufi, Abdenour; Garcia, Meilin Fernandez; Jaroszewicz, Artur; et al. (2015). Pioneer Transcription Factors Target Partial DNA Motifs on Nucleosomes to Initiate Reprogramming. CELL. 161(3): 555-568

Zaret, Kenneth S.; Carroll, Jason S. (2011). Pioneer transcription factors: establishing competence for gene expression. GENES & DEVELOPMENT. 25 (21): 2227-2241

 
 

Recommended Readings: Thomas P. Sakmar, M.D., Monday May 22th, 2017

Monday Lectures

Monday, May 22, 2017  3:45 p.m.

Carson Family Auditorium

Thomas P. Sakmar, M.D.

Richard M. and Isabel P. Furlaud Professor and Head,

Laboratory of Chemical Biology and Signal Transduction

The Rockefeller University

Uveal Melanoma: Case History of a Mutant GPCR

Recommended Readings:

https://medicalxpress.com/news/2017-04-newly-chemical-reaction-eye-vision.html

Chua V, Lapadula D, Randolph C, Benovic JL, Wedegaertner PB, Aplin AE. (2017). Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. MOLECULAR CANCER RESEARCH. 15(5):501-506

Moore, Amanda R.; Ceraudo, Emilie; Sher, Jessica J.; et al. (2016). Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. NATURE GENETICS. 48(6): 675-+

Shoushtari, Alexander N.; Carvajal, Richard D. (2014). GNAQ and GNA11 mutations in uveal melanoma. MELANOMA RESEARCH. 24(6): 525-534. PLEASE REQUEST FROM MARKUS LIBRARY.

Harbour, J. William (2012). The genetics of uveal melanoma: an emerging framework for targeted therapy. PIGMENT CELL & MELANOMA RESEARCH. 25(2)

Periole, Xavier; Knepp, Adam M.; Sakmar, Thomas P.; et al. (2012). Structural Determinants of the Supramolecular Organization of G Protein-Coupled Receptors in Bilayers. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 134(26): 10959-10965