Friday Lectures
Friday, September 7, 2018 3:45 p.m.
Caspary Auditorium
John Hardy Ph.D.
Head of the Department of Molecular Neuroscience
Chair of the Molecular Biology of Neurological Disease
University College London
Genomic Analysis of Alzheimer’s Disease and other Neurodegenerative Disorders
Recommended Readings:
Science News
Rebecca Hiscott. AT THE BENCH: John Hardy, PhD, on Unraveling the Genetics of Alzheimer’s Disease and Attending the ‘Oscars of Science’. January 7, 2016. Neurology Today
Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk. November 14, 2012. ALZFORUM
Empirical Articles
Karch, Celeste M.; Wen, Natalie; Fan, Chun C.; et al. (2018). Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum. JAMA NEUROLOGY. 75 (7): 860-875
Sims, Rebecca; van der Lee, Sven J.; Naj, Adam C.; et al. (2017). Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease. NATURE GENETICS. 49 (9): 1373-+
Wang, Yaming; Cella, Marina; Mallinson, Kaitlin; et al. (2015).TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model. CELL. 160 (6):1061-1071
Nalls, Mike A.; Pankratz, Nathan; Lill, Christina M.; et al. (2014). Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease. NATURE GENETICS. 46 (9): 989-+
Guerreiro, Rita; Wojtas, Aleksandra; Bras, Jose; et al. (2013). TREM2 Variants in Alzheimer’s Disease. NEW ENGLAND JOURNAL OF MEDICINE. 368 (2): 355-358
Jones, Lesley; Holmans, Peter A.; Hamshere, Marian L.; et al. (2010). Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer’s Disease. PLOS ONE. 5 (11)
Hardy, J; Duff, K; Hardy, KG; Perez-Tur, J; Hutton, M; (1998). Genetic dissection of Alzheimer’s disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1 (5): 355 – 358
Hardy JA, Higgins GA. (1992). Alzheimer’s disease: the amyloid cascade hypothesis. Science. 256 5054):184-5
Review Paper
Hardy, John. (2017). The discovery of Alzheimer-causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”. FEBS JOURNAL. 284 (7): 1040-1044
Selkoe, Dennis J.; Hardy, John. (2016). The amyloid hypothesis of Alzheimer’s disease at 25years. EMBO MOLECULAR MEDICINE. 8 (6): 595-608
Hampel, Harald; Frank, Richard; Broich, Karl; et al. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. NATURE REVIEWS DRUG DISCOVERY. 9 (7): 560-574
Book Chapter
Yu, Jin-Tai; Tan, Lan; Hardy, John. (2014). Apolipoprotein E in Alzheimer’s Disease: An Update. ANNUAL REVIEW OF NEUROSCIENCE. 37: 79-100
Hardy, John. (2012). Alzheimer’s disease and related dementias. NEUROGENETICS: A GUIDE FOR CLINICIANS. 17-31