Friday Lectures
Friday, January 10, 2020 3:45 p.m
Caspary Auditorium
Christine Seidman, M.D.
Thomas W. Smith Professor of Medicine and Genetics
Cardiovascular Genetics Center
Harvard Medical School
Mutations, Mechanisms, and New Medicines for Cardiomyopathies
Recommended Readings:
Empirical Articles
Toepfer, Christopher N.; Sharma, Arun; Cicconet, Marcelo; et al. (2019). SarcTrack An Adaptable Software Tool for Efficient Large-Scale Analysis of Sarcomere Function in hiPSC-Cardiomyocytes. CIRCULATION RESEARCH. 124 (8): 1172-1183
Tan, Chia Yee; Wong, Jing Xuan; Chan, Pui Shi; et al. (2019). Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf. CIRCULATION RESEARCH. 125 (9): 834-846
Chang, Alex C. Y.; Chang, Andrew C. H.; Kirillova, Anna; et al. (2018). Telomere shortening is a hallmark of genetic cardiomyopathies. PNAS. 15 (37): 9276-9281
Huttner, Inken G.; Wang, Louis W.; Santiago, Celine F.; et al. (2018). A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance. CIRCULATION-GENOMIC AND PRECISION MEDICINE. 11 (8)
Green, Eric M.; Wakimoto, Hiroko; Anderson, Robert L.; et al. (2016). A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. SCIENCE. 351 (6273): 617-621
Hinson, John T.; Chopra, Anant; Nafissi, Navid; et al. (2015). Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy. SCIENCE. 349 (6251): 982-986
Herman, Daniel S.; Lam, Lien; Taylor, Matthew R. G.; et al. (2012). Truncations of Titin Causing Dilated Cardiomyopathy. NEW ENGLAND JOURNAL OF MEDICINE. 366 (7): 619-628
Review Papers
Fatkin, Diane; Huttner, Inken G.; Kovacic, Jason C.; et al. (2019). Precision Medicine in the Management of Dilated Cardiomyopathy JACC State-of-the-Art Review. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 74 (23): 2921-2938
Hershberger, Ray E.; Lindenfeld, Joann; Mestroni, Luisa; et al. (2009). Genetic Evaluation of Cardiomyopathy-A Heart Failure Society of America Practice Guideline. JOURNAL OF CARDIAC FAILURE. 15 (2): 83-97
Book Chapter
Yotti, Raquel; Seidman, Christine E.; Seidman, Jonathan G. (2019). Advances in the Genetic Basis and Pathogenesis of Sarcomere Cardiomyopathies. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS. 20: 129-153