Hybrid Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, March 8, 2024
Gerd Blobel, M.D., Ph.D.
Frank E. Weise Professor of Pediatrics, University of Pennsylvania School of Medicine
Understanding Normal and Dysfunctional Gene Regulation through the Lens of the Hemoglobin Genes
Recommended Readings:
Qin, Kunhua, et al. “Molecular basis of polycomb group protein–mediated fetal hemoglobin repression.” Blood, The Journal of the American Society of Hematology 141.22 (2023): 2756-2770.
Khandros, Eugene, and Gerd A. Blobel. “Heterogeneity of fetal hemoglobin production in adult red blood cells.” Current opinion in hematology 28.3 (2021): 164.
Paikari, Alireza, and Vivien A. Sheehan. “Fetal haemoglobin induction in sickle cell disease.” British journal of haematology 180.2 (2018): 189-200.
Philipsen, Sjaak, and Ross C. Hardison. “Evolution of hemoglobin loci and their regulatory elements.” Blood Cells, Molecules, and Diseases 70 (2018): 2-12.
Sankaran, Vijay G., et al. “Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.” Science 322.5909 (2008): 1839-1842.
