Friday Lecture Series
(open to the Rockefeller community)
Friday, September 30, 2022
Nevan Krogan, Ph.D.
Director of the HARC Center,
Co-Director of the Cancer Cell Mapping Initiative (CCMI), the Host Pathogen Map Initiative (HPMI) and the Psychiatric Cell Map Initiative (PCMI),
Director of the California Institute for Quantitative Biosciences,
Director of the Quantitative Biosciences Institute,
Senior Investigator of the J. David Gladstone Institutes,
Professor, Cellular Molecular Pharmacology,
University of California, San Francisco
Using Systems Approaches to Understand Mechanisms in Disease
Recommended Readings:
Empirical Articles
Chen, H., Diolaiti, M. E., O’Leary, P. C., Rojc, A., Krogan, N. J., Kim, M., & Ashworth, A. (2022). A Whole-Genome CRISPR Screen Identifies AHR Loss as a Mechanism of Resistance to a PARP7 Inhibitor. Molecular cancer therapeutics, 21(7), 1076–1089.
Johnson, J. R., Crosby, D. C., Hultquist, J. F., Kurland, A. P., Adhikary, P., Li, D., Marlett, J., Swann, J., Hüttenhain, R., Verschueren, E., Johnson, T. L., Newton, B. W., Shales, M., Simon, V. A., Beltrao, P., Frankel, A. D., Marson, A., Cox, J. S., Fregoso, O. I., Young, J. A. T., & Krogan, N. J. (2022). Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling. Cell reports, 39(2), 110690.
Hiatt, J., Hultquist, J. F., McGregor, M. J., Bouhaddou, M., Leenay, R. T., Simons, L. M., Young, J. M., Haas, P., Roth, T. L., Tobin, V., Wojcechowskyj, J. A., Woo, J. M., Rathore, U., Cavero, D. A., Shifrut, E., Nguyen, T. T., Haas, K. M., Malik, H. S., Doudna, J. A., May, A. P., Marson, A., & Krogan, N. J. (2022). A functional map of HIV-host interactions in primary human T cells. Nature communications, 13(1), 1752.
Gordon, D. E., Hiatt, J., Bouhaddou, M., Rezelj, V. V., Ulferts, S., Braberg, H., Jureka, A. S., Obernier, K., Guo, J. Z., Batra, J., Kaake, R. M., Weckstein, A. R., Owens, T. W., Gupta, M., Pourmal, S., Titus, E. W., Cakir, M., Soucheray, M., McGregor, M., Cakir, Z., … Krogan, N. J. (2020). Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science, 370(6521), eabe9403.
