Monday Lecture Series
(open to the Rockefeller community)
Monday, November 8, 2021
Sidney Strickland, Ph.D.
Zachary and Elizabeth M. Fisher Professor in Alzheimer’s and Neurodegenerative Disease
Head of the Patricia & John Rosenwald Laboratory of Neurobiology and Genetics
Vice President for Educational Affairs
Dean of Graduate and Postgraduate Studies
The Rockefeller University
The Clot Thickens: Coagulation and Inflammation are Drivers and Therapeutic Targets in Alzheimer’s Disease
Recommended Readings:
Empirical Articles
Tataryn, N. M., Singh, V., Dyke, J. P., Berk-Rauch, H. E., Clausen, D. M., Aronowitz, E., Norris, E. H., Strickland, S., & Ahn, H. J. (2021). Vascular endothelial growth factor associated dissimilar cerebrovascular phenotypes in two different mouse models of Alzheimer’s Disease. Neurobiology of Aging, 107, 96–108.
Cajamarca, S. A., Norris, E. H., van der Weerd, L., Strickland, S., & Ahn, H. J. (2020). Cerebral amyloid angiopathy-linked β-amyloid mutations promote cerebral fibrin deposits via increased binding affinity for fibrinogen. Proceedings of the National Academy of Sciences of the United States of America, 117(25), 14482–14492.
Chen, Z. L., Singh, P., Wong, J., Horn, K., Strickland, S., & Norris, E. H. (2019). An antibody against HK blocks Alzheimer’s disease peptide β-amyloid-induced bradykinin release in human plasma. Proceedings of the National Academy of Sciences of the United States of America, 116(46), 22921–22923.
Cruz Hernández JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M, Park L, Vinarcsik LK, Ivasyk I, Rivera DA, Kang Y, Cortes-Canteli M, Peyrounette M, Doyeux V, Smith A, Zhou J, Otte G, Beverly JD, Davenport E, Davit Y, Lin CP, Strickland S, Iadecola C, Lorthois S, Nishimura N, Schaffer CB. (2019) Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer’s disease mouse models. Nature Neuroscience, 22(3):413-420.
Singh, P. K., Berk-Rauch, H. E., Soplop, N., Uryu, K., Strickland, S., & Ahn, H. J. (2018). Analysis of β-Amyloid-induced Abnormalities on Fibrin Clot Structure by Spectroscopy and Scanning Electron Microscopy. Journal of Visualized Experiments : JoVE, (141), 10.3791/58475.
Review Articles
Singh, P. K., Badimon, A., Chen, Z. L., Strickland, S., & Norris, E. H. (2021). The contact activation system and vascular factors as alternative targets for Alzheimer’s disease therapy. Research and practice in thrombosis and haemostasis, 5(4), e12504.
Strickland S. (2018). Blood will out: vascular contributions to Alzheimer’s disease. The Journal of Clinical Investigation, 128(2), 556–563.
