Monday Lectures
Monday, March 9, 2020 4:00 p.m.
Carson Family Auditorium
Marina Caskey, M.D.
Associate Professor of Clinical Investigation
Laboratory of Molecular Immunology
The Rockefeller University
Broadly Neutralizing Antibodies for HIV Prevention, Therapy and Cure
Recommended Readings:
Science News
Antibody combo controls HIV for months. September 26, 2018. FierceBiotech
Empirical Articles
Niessl, Julia; Baxter, Amy E.; Mendoza, Pilar; et al. (2020). Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity. NATURE MEDICINE. 26 (2): 222-227
Cohen, Yehuda Z.; Butler, Allison L.; Millard, Katrina; et al. (2019). Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study. PLOS ONE. 14 (8)
Bar-On, Yotam; Gruell, Henning; Schoofs, Till; et al. (2018). Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals. NATURE MEDICINE. 24 (11): 1701-+
Mendoza, Pilar; Gruell, Henning; Nogueira, Lilian; et al. (2018). Combination therapy with anti-HIV-1 antibodies maintains viral suppression. NATURE. 561 (7724): 479-+
Cohen, Yehuda Z.; Lorenzi, Julio C. C.; Krassnig, Lisa; et al. (2018). Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117. JOURNAL OF EXPERIMENTAL MEDICINE. 215 (9): 2311-2324
Cohen, Yehuda Z.; Lorenzi, Julio C. C.; Seaman, Michael S.; et al. (2018). Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells. JOURNAL OF VIROLOGY. 92 (5)
Caskey, Marina; Schoofs, Till; Gruell, Henning; et al. (2017). Antibody 10-1074 suppresses viremia in HIV-1-infected individuals. NATURE MEDICINE. 23 (2): 185-191
Review Papers
Caskey, Marina; Klein, Florian; Nussenzweig, Michel C. (2019). Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic. NATURE MEDICINE. 25 (4): 547-553
Cohen, Yehuda Z.; Caskey, Marina. (2018). Broadly neutralizing antibodies for treatment and prevention of HIV-1 infection. CURRENT OPINION IN HIV AND AIDS. 13 (4): 366-373