Monday Lectures
Monday, March 2, 2020 4:00 p.m.
Carson Family Auditorium
Michael O’Donnell, Ph.D.
Anthony and Judith Evnin Professor and Head
Laboratory of DNA Replication
The Rockefeller University
What’s New in DNA Replication?
Recommended Readings:
Empirical Articles
Lewis, Jacob S.; Spenkelink, Lisanne M.; Schauer, Grant D.; et al. (2020). Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication. MOLECULAR CELL. 77 (1): 17-+
Yuan, Zuanning; Georgescu, Roxana; Santos, Ruda de Luna Almeida; et al. (2019). Ctf4 organizes sister replisomes and Pol alpha into a replication factory. ELIFE. 8
Wasserman, Michael R.; Schauer, Grant D.; O’Donnell, Michael E.; et al. (2019). Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase. CELL. 178 (3): 600-+
Georgescu, Roxana; Yuan, Zuanning; Bai, Lin; et al. (2017). Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation. PNAS. 114 (5): E697-E706
Schauer, Grant D.; O’Donnell, Michael E. (2017). Quality control mechanisms exclude incorrect polymerases from the eukaryotic replication fork. PNAS. 114 (4): 675-680
Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E.; et al. (2015). The architecture of a eukaryotic replisome. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 22 (12): 976-982
Review Paper
Li, Huilin; O’Donnell, Michael E. (2018). The Eukaryotic CMG Helicase at the Replication Fork: Emerging Architecture Reveals an Unexpected Mechanism. BIOESSAYS. 40 (3)
Book Chapter
Bai, Lin; Yuan, Zuanning; Sun, Jingchuan; et al. (2017). Architecture of the Saccharomyces cerevisiae Replisome. DNA REPLICATION: FROM OLD PRINCIPLES TO NEW DISCOVERIES. 1042: 207-228