Friday Lectures
Friday, October 11, 2019 3:45 p.m
Caspary Auditorium
Adrian Bird Ph.D.
Buchanan Professor of Genetics
The University of Edinburgh
The Genetics and Epigenetics of Rett Syndrome
Recommended Readings:
Empirical Articles
Cholewa-Waclaw, Justyna; Shah, Ruth; Webb, Shaun; et al. (2019). Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic. PNAS. 116 (30): 14995-15000
Guy, Jacky; Alexander-Howden, Beatrice; FitzPatrick, Laura; et al. (2018). A mutation-led search for novel functional domains in MeCP2. HUMAN MOLECULAR GENETICS. 27 (14): 2531-2545
Tillotson, Rebekah; Selfridge, Jim; Koerner, Martha V.; et al. (2017). Radically truncated MeCP2 rescues Rett syndromelike neurological defects. NATURE. 550 (7676): 398-401
Kruusvee, Valdeko; Lyst, Matthew J.; Taylor, Ceitidh; et al. (2017). Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders. PNAS. 114 (16): E3243-E3250
Cholewa-Waclaw, Justyna; Bird, Adrian; von Schimmelmann, Melanie; et al. (2016). The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System. JOURNAL OF NEUROSCIENCE. 36 (45): 11427-11434
Guy, Jacky; Gan, Jian; Selfridge, Jim; et al. (2007). Reversal of neurological defects in a mouse model of Rett syndrome. SCIENCE. 315 (5815): 1143-1147
Review Papers
Katz, David M.; Bird, Adrian; Coenraads, Monica; et al. (2016). Rett Syndrome: Crossing the Threshold to Clinical Translation. TRENDS IN NEUROSCIENCES. 39 (2): 100-113
Lyst, Matthew J.; Bird, Adrian. (2015). Rett syndrome: a complex disorder with simple roots. NATURE REVIEWS GENETICS. 16 (5): 261-274
Kriaucionis, S; Bird, A. (2003). DNA methylation and Rett syndrome. HUMAN MOLECULAR GENETICS. 12 (2): R221-R227
Book Chapter
Guy, Jacky; Cheval, Helene; Selfridge, Jim; et al. (2011). The Role of MeCP2 in the Brain. BOOK SERIES: ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 27: 631-652