Friday Lecture Series
Norton Zinder Lecture
Michael Levine, Ph.D.
Director, Lewis-Sigler Institute for Integrative Genomics, Princeton Univ.
Anthony B. Evnin Professor, Dept Molecular Biology, Princeton Univ.
Visualization and evolution of transcriptional enhancers
Recommended Readings:
Bothma, J.P., Garcia, H.G., Ng, S., Perry, M.W., Gregor, T., and Levine, M. (2015). Enhancer additivity and nonadditivity are determined by enhancer strength in the Drosophila embryo. eLife 4, 07956.
Farley, E.K., Olson, K.M., Zhang, W., Brandt, A.J., Rokhsar, D.S., and Levine, M. (2015). Suboptimization of developmental enhancers. Science 350, 325-328.
Fukaya, T., Lim, B., and Levine, M. 2016. Enhancer control of transcriptional bursting. Cell 166, 358-368.
Bothma, J., Garcia, H., Gavin, S., Esposito, E., Gregor, T., and Levine, M. (2014). Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophila embryos. PNAS 111, 10598-10603.
Evans, Nicole C.; Swanson, Christina I.; Barolo, Scott. Sparkling Insights into Enhancer Structure, Function, and Evolution. TRANSCRIPTIONAL SWITCHES DURING DEVELOPMENT Book Series: Current Topics in Developmental Biology . 98: 97-120 2012
Gordon, Kacy L.; Ruvinsky, Ilya. Tempo and Mode in Evolution of Transcriptional Regulation. PLOS GENETICS. 8(1): e1002432 2012
