Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, March 28, 2025
Stephen West, Ph.D., FMedSci
Principal Group Leader, The Francis Crick Institute
Maintaining our Genome:- It Takes Two to Tango
The William H Stein Memorial Lecture
Recommended Readings:
Jiang, Huadong, et al. “BPS2025-Mechanosensory function of ANKLE1 endonuclease in processing chromatin bridges by cleaving mechanically strained DNA.” Biophysical Journal 124.3 (2025): 567a.
Liang, Chih-Chao, et al. “Mechanism of single-stranded DNA annealing by RAD52–RPA complex.” Nature 629.8012 (2024): 697-703.
Jiang, Huadong, et al. “Human endonuclease ANKLE1 localizes at the midbody and processes chromatin bridges to prevent DNA damage and cGAS‐STING activation.” Advanced Science 10.12 (2023): 2204388.
Belan, Ondrej, et al. “POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.” Molecular cell 82.24 (2022): 4664-4680.
Young, Sarah J., and Stephen C. West. “Coordinated roles of SLX4 and MutSβ in DNA repair and the maintenance of genome stability.” Critical reviews in biochemistry and molecular biology 56.2 (2021): 157-177.
