Chemical & Structural Biology Seminar Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, April 15, 2025
Shu-ou Shan, Ph.D.
Altair Professor of Chemistry and Executive Officer for Biochemistry and Molecular Biophysics, California Institute of Technology
Decision Making during Protein Biogenesis: on the Ribosome and Beyond
Recommended Readings:
Lentzsch, Alfred M., et al. “NAC guides a ribosomal multienzyme complex for nascent protein processing.” Nature 633.8030 (2024): 718-724.
Zhu, Zikun, Shuai Wang, and Shu-ou Shan. “Ribosome profiling reveals multiple roles of SecA in cotranslational protein export.” Nature communications 13.1 (2022): 3393.
Yang, Chien-I., Jiwoo Kim, and Shu-ou Shan. “Ribosome-nascent chain interaction regulates N-terminal protein modification.” Journal of molecular biology 434.9 (2022): 167535.
Jomaa, Ahmad, et al. “Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting.” Science 375.6583 (2022): 839-844.
Yang, Chien-I., Hao-Hsuan Hsieh, and Shu-ou Shan. “Timing and specificity of cotranslational nascent protein modification in bacteria.” Proceedings of the National Academy of Sciences 116.46 (2019): 23050-23060.
