Hybrid Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 17, 2024
Jonathan Weissman, Ph.D.
Professor of Biology, Member, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Member and Landon T. Clay Professor of Biology, Whitehead Institute for Biomedical Research; Investigator, Howard Hughes Medical Institute
Brain-wide Silencing of Prion Protein and Treatment of Prion Diseases by AAV-Mediated Delivery of CHARM an Engineered Compact Epigenetic Editor
The Jerry A. Weisbach Memorial Lecture
Recommended Readings:
Villiger, Lukas, et al. “CRISPR technologies for genome, epigenome and transcriptome editing.” Nature Reviews Molecular Cell Biology (2024): 1-24.
Guna, Alina, et al. “A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.” BMC genomics 24.1 (2023): 651.
Nuñez, James K., et al. “Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.” Cell 184.9 (2021): 2503-2519.
Xu, Christine L., et al. “Viral delivery systems for CRISPR.” Viruses 11.1 (2019): 28.
Li, Bin-Zhong, et al. “Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase.” Cell research 21.8 (2011): 1172-1181.
