Monday Lecture Series
(open to the Rockefeller community)
Monday, December 19, 2022
Jeremy Rock, Ph.D.
Penrhyn E. Cook Assistant Professor,
Head of the Laboratory of Host-Pathogen Biology,
The Rockefeller University
A chemical-genetic map of drug resistance in Mycobacterium tuberculosis
Recommended Readings:
Empirical Articles
Poulton, N. C., Azadian, Z. A., DeJesus, M. A., & Rock, J. M. (2022). Mutations in rv0678 Confer Low-Level Resistance to Benzothiazinone DprE1 Inhibitors in Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 66(9), e0090422.
Theriault, M. E., Pisu, D., Wilburn, K. M., Lê-Bury, G., MacNamara, C. W., Michael Petrassi, H., Love, M., Rock, J. M., VanderVen, B. C., & Russell, D. G. (2022). Iron limitation in M. tuberculosis has broad impact on central carbon metabolism. Communications biology, 5(1), 685.
Li, S., Poulton, N. C., Chang, J. S., Azadian, Z. A., DeJesus, M. A., Ruecker, N., Zimmerman, M. D., Eckartt, K. A., Bosch, B., Engelhart, C. A., Sullivan, D. F., Gengenbacher, M., Dartois, V. A., Schnappinger, D., & Rock, J. M. (2022). CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosis. Nature microbiology, 7(6), 766–779.
d’Andrea, F. B., Poulton, N. C., Froom, R., Tam, K., Campbell, E. A., & Rock, J. M. (2022). The essential M. tuberculosis Clp protease is functionally asymmetric in vivo. Science advances, 8(18), eabn7943.
Reviews
Poulton, N. C., & Rock, J. M. (2022). Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis. Frontiers in cellular and infection microbiology, 12, 997283.
