Friday Lectures
Friday, June 7, 2019 3:45 p.m
Caspary Auditorium
Paola Arlotta Ph.D.
Professor
Department of Stem Cell and Regenerative Biology
Harvard University
Understanding Cortical Development and Disease: From Embryos to Brain Organoids
Recommended Readings:
Science News
What you need to know about organoids. March 15, 2019. Journalist’s Resource
Empirical Articles
Arlotta, Paola. (2018). Organoids required! A new path to understanding human brain development and disease. NATURE METHODS. 15 (1): 27-29
Quadrato, Giorgia; Tuan Nguyen; Macosko, Evan Z.; et al. (2017). Cell diversity and network dynamics in photosensitive human brain organoids. NATURE. 545 (7652): 48-+
Molyneaux, Bradley J.; Goff, Loyal A.; Brettler, Andrea C.; et al. (2015). DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex. NEURON. 85 (2): 275-288
Quadrato, Giorgia; Brown, Juliana; Arlotta, Paola (2016). The promises and challenges of human brain organoids as models of neuropsychiatric disease. NATURE MEDICINE. 22 (11): 1220-1228
Review Papers
Quadrato, Giorgia; Arlotta, Paola (2017). Present and future of modeling human brain development in 3D organoids. CURRENT OPINION IN CELL BIOLOGY. 49: 47-52
Lodato, Simona; Shetty, Ashwin S.; Arlotta, Paola (2015). Cerebral cortex assembly: generating and reprogramming projection neuron diversity. TRENDS IN NEUROSCIENCES. 38 (2): 117-125
Harris, James; Tomassy, Giulio Srubek; Arlotta, Paola (2015). Building blocks of the cerebral cortex: from development to the dish. WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY. 4 (5): 529-544
Book Chapters
Brown, Juliana; Quadrato, Giorgia; Arlotta, Paola (2018). Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. HUMAN EMBRYONIC STEM CELLS IN DEVELOPMENT. 129: 99-122
Lodato, Simona; Arlotta, Paola (2015). Generating Neuronal Diversity in the Mammalian Cerebral Cortex. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY. 31: 699-720