Recommended Readings: Lewis Cantley, Ph.D. Friday March 16, 2018

Recommended Readings: Lewis Cantley, Ph.D. Friday March 16, 2018

Friday LecturesLewis Cantley

Friday, March 16, 2018  3:45 p.m.

Caspary Auditorium

Lewis Cantley, Ph.D.

Meyer Director of the Sandra and Edward Meyer Cancer Center

and

Professor of Cancer Biology in Medicine

Weill Cornell Medicine and New York-Presbyterian Hospital

PI 3-Kinase: Linking Obesity, Insulin Resistance, and Cancer

Recommended Readings:

Empirical Articles

Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. (2018). Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer. CANCER DISCOVERY. 8 (3):354-369

Waldhart, Althea N.; Dykstra, Holly; Peck, Anderson S.; et al. (2017).  Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. CELL REPORTS. 19 (10): 2005-2013

Croessmann S, Sheehan JH, Lee KM, Sliwoski G, et al. (2017). PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. CLINICAL CANCER RESEARCH. doi: 10.1158/1078-0432.CCR-17-2141

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4): 605-635

Thorpe, Lauren M.; Spangle, Jennifer M.; Ohlson, Carolynn E.; et al. (2017). PI3K-p110 alpha mediates the oncogenic activity induced by loss of the novel tumor suppressorPI3K-p85 alpha. PNAS.114 (27): 7095-7100

Juvekar, Ashish; Hu, Hai; Yadegarynia, Sina; et al. (2016). Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. PNAS. 113 (30): E4338-E4347

Review Papers

Fruman, David A.; Chiu, Honyin; Hopkins, Benjamin D.; et al. (2017). The PI3K Pathway in Human Disease. CELL. 170 (4): 605-635

Heiden, Matthew G. Vander; Cantley, Lewis C.; Thompson, Craig B. (2009). Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation. SCIENCE. 324 (5930): 1029-1033

Yuan, T. L.; Cantley, L. C. (2008). PI3K pathway alterations in cancer: variations on a theme. ONCOGENE. 27 (41): 5497-5510

Book Chapter

Lien, Evan C.; Lyssiotis, Costas A.; Cantley, Lewis C. (2016). Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. METABOLISM IN CANCER. 207: 39-72

Yuan, Tina L.; Cantley, Lewis C. (2010). Phosphoinositide 3-kinase in Health and Disease Volume 1 Introduction. PHOSPHOINOSITIDE 3-KINASE IN HEALTH AND DISEASE, VOL1. Current Topics in Microbiology and Immunology. 346: 1-7

 

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About the Author:

Ilaria Ceglia, Ph.D., Science Informationist - Ilaria joined the Markus Library Team in 2017. As science liaison between the Rockefeller scientific community and the library, Ilaria assists Rockefeller scientists find, and effectively use, the scholarly communication tools available at the library, provides customized literature searching, delivers research information reports and publications metric analysis to enhance collaborations between Rockefeller and leading scientific institutions, provides access to digital content to manage large data freely accessible. Ilaria manages a drug development database to perform clinical literature searches and drugs pipeline reports for Rockefeller research faculty, scientists and clinicians. As the NIH compliance monitor for the Rockefeller University, Ilaria helps faculty to solve scientific submission requirements issues and ensures Rockefeller remains compliant with NIH Public Access Policy. Her role also includes evaluate and select new databases to complement other resource center services, organize tutorial training sessions in areas of life sciences and on the use of reference management platforms F1000 Workspace, Scopus, Web of Science and PubMed literature searching, managing recommendation readings library blog for lectures and special seminars. Ilaria is a neuroscientist and a former Rockefeller postdoctoral and research associate of Dr. Paul Greengard’s laboratory. She was a Research Assistant Professor at the Icahn School of Medicine at Mount Sinai, New York and an Adjunct Assistant Professor at City College and Hunter College in New York, where she taught Cell Biology and Biochemistry. As an Italian expat living in New York, Ilaria is an enthusiastic proponent of Italian culture among friends and colleagues.