Friday Lectures
Friday, December 8, 2017 3:45 p.m.
Caspary Auditorium
Philip Cole, M.D., Ph.D.
Professor
Department of Medicine, Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Targeting Reversible Lysine Acetylation with Designed Small Molecules
Recommended Readings:
Empirical Articles
Boija, Ann; Mahat, Dig Bijay; Zare, Aman; et al. (2017). CBP Regulates Recruitment and Release of Promoter–Proximal RNA Polymerase II. MOLECULAR CELL. 68 (3): 491-+
Lasko, Loren M.; Jakob, Clarissa G.; Edalji, Rohinton P.; et al. (2017). Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours. NATURE. 550 (7674): 128-+
Maksimoska, Jasna; Segura-Pena, Dario; Cole, Philip A.; et al. (2014). Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues. BIOCHEMISTRY. 53 (21): 3415-3422
Bowers, Erin M.; Yan, Gai; Mukherjee, Chandrani; et al. (2010). Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor. CHEMISTRY & BIOLOGY. 17 (5): 471-482
Dancy, Beverley M.; Crump, Nicholas T.; Peterson, Daniel J.; et al. (2012). Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition. CHEMBIOCHEM. 13 (14): 2113-2121
Liu, Xin; Wang, Ling; Zhao, Kehao; et al. (2008). The structural basis of protein acetylation by the p300/CBP transcriptional coactivator. NATURE. 451 (7180): 846-850
Review Papers
Dancy, Beverley M.; Cole, Philip A. (2013). Protein Lysine Acetylation by p300/CBP. CHEMICAL REVIEWS. 115 (6): 2419-2452
Cole, Philip A. (2008). Chemical probes for histone-modifying enzymes. NATURE CHEMICAL BIOLOGY. 4 (10): 590-597
