Friday Lectures
Friday, January 6, 3:45 p.m.
Caspary Auditorium
Stuart H. Orkin M.D.
David G. Nathan Distinguished Professor of Pediatrics, Dana Farber Institute
The Human Fetal Globin Switch:
A Paradigm for Disease-related Common Genetic Variation in Regulatory Elements
Recommended Readings:
Bauer, Daniel E.; Kamran, Sophia C.; Lessard, Samuel; et al. An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level. SCIENCE 342(6155): 253-257 OCT 11 2013
Galarneau, Genevieve; Palmer, Cameron D.; Sankaran, Vijay G.; et al. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation. NATURE GENETICS 42(12): 1049-1051 DEC 2010
Menzel, Stephan; Thein, Swee Lay. Genetic architecture of hemoglobin F control. CURRENT OPINION IN HEMATOLOGY 16(3): 179-186 MAY 2009 PLEASE REQUEST FROM MARKUS LIBRARY
He, Yunyan; Lin, Weixiong; Luo, Jianming. Influences of Genetic Variation on Fetal Hemoglobin. PEDIATRIC HEMATOLOGY AND ONCOLOGY Volume: 28 Issue: 8 Pages: 708-717 Published: NOV 2011 PLEASE REQUEST FROM MARKUS LIBRARY.
Orkin, Stuart H. Recent advances in globin research using genome-wide association studies and gene editing. Annals of the New York Academy of Sciences 1368 : 5-10 2016
