Friday Lectures
Friday, November 18, 2016 3:45 p.m.
Caspary Auditorium
Tania Baker, Ph.D.
Edwin C. Whitehead Professor of Biology, MIT
Investigator, HHMI
Operations of AAA+ Unfoldase Motors:
Powerful Destroyers and Activators of Protein Function
Selected Publications:
Baker, Tania A.; Sauer, Robert T. ClpXP, an ATP-powered unfolding and protein-degradation machine. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1823(Special Issue SI): 15-28 JAN 2012
Stinson, Benjamin M.; Nager, Andrew R.; Glynn, Steven E.; et al. Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA plus Machine. CELL 153(3):628-639 APR 25 2013
Glynn, Steven E.; Nager, Andrew R.; Baker, Tania A.; et al. Dynamic and static components power unfolding in topologically closed rings of a AAA plus proteolytic machine. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 19(6):616-+ JUN 2012
Cordova, Juan Carlos; Olivares, Adrian O.; Shin, Yongdae; et al. Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine. CELL 158(3): 647-658 JUL 31 2014
Olivares, Adrian O.; Nager, Andrew R.; Iosefson, Ohad; et al. Mechanochemical basis of protein degradation by a double-ring AAA plus machine. NATURE STRUCTURAL & MOLECULAR BIOLOGY 21(10): 871-875 OCT 2014
