Monday Lectures
December 12, 2016
4:00 p.m. Carson Family Auditorium CRC
Michael O’Donnell Ph.D.
HHMI Investigator, and Anthony and Judith Evnin Professor
Laboratory of DNA Replication
The Rockefeller University
The Eukaryotic Replisome
Recommended Readings:
O’Donnell, Mike; Li, Huilin The Eukaryotic Replisome Goes Under the Microscope. CURRENT BIOLOGY 26(6): R247-R256 MAR 21 2016
Yuan, Zuanning; Bai, Lin; Sun, Jingchuan; et al. Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation. NATURE STRUCTURAL & MOLECULAR BIOLOGY 23(3): 217-224 MAR 2016
Sun, Jingchuan; Shi, Yi; Georgescu, Roxana E.; et al. The architecture of a eukaryotic replisome. NATURE STRUCTURAL & MOLECULAR BIOLOGY 22(12): 976-982 DEC 2015
Georgescu, Roxana E.; Schauer, Grant D.; Yao, Nina Y.; et al. Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation. ELIFE 4: e04988 APR 14 2015
O’Donnell, Michael; Langston, Lance; Stillman, Bruce Principles and Concepts of DNA Replication in Bacteria, Archaea, and Eukarya . COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY 5(7): a010108
