Friday Lecture Series
Friday, March 25
3:45 p.m., Caspary Auditorium
Bruce Beutler, M.D.
Regental Professor,
Director, Center for the Genetics of Host Defense,
Raymond and Ellen Willie Distinguished Chair in Cancer Research,
University of Texas Southwestern Medical Center
Saturation Mutagenesis of the Mouse Genome with Real-time Identification of Causative Mutations
Recommended Readings
Empirical Articles
Shi, H., Wang, Y., Li, X., Zhan, X., Tang, M., Fina, M., … & Beutler, B. (2015). NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nature Immunology. 17(3), 250-258. doi: 10.1038/ni.3333.
Wang, T., Zhan, X., Bu, C. H., Lyon, S., Pratt, D., Hildebrand, S., … & Beutler, B. (2015). Real-time resolution of point mutations that cause phenovariance in mice. Proceedings of the National Academy of Sciences, 112(5), E440-E449. doi: 10.1073/pnas.1423216112.
Review Paper
Simon, M. M., Moresco, E. M. Y., Bull, K. R., Kumar, S., Mallon, A. M., Beutler, B., & Potter, P. K. (2015). Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing. Mammalian Genome, 26(9-10), 486-500. doi: 10.1007/s00335-015-9603-x
