Friday Lecture Series
Friday, January 29, 2016
3:45 p.m., Caspary Auditorium
John Kuriyan, Ph.D.
Professor,
Department of Molecular and Cell Biology,
Department of Chemistry,
University of California, Berkeley,
Investigator, Howard Hughes Medical Institute
Control of Catalytic Activity in the EGF Receptor
Recommended Reading
Empirical Articles
Jura, N., Shan, Y., Cao, X., Shaw, D. E., & Kuriyan, J. (2009). Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3. Proceedings of the National Academy of Sciences, 106(51), 21608-21613. doi:10.1073/pnas.0912101106.
Zhang, X., Gureasko, J., Shen, K., Cole, P. A., & Kuriyan, J. (2006). An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor. Cell, 125(6), 1137-1149. doi:10.1016/j.cell.2006.05.013
Zhang, X., Pickin, K. A., Bose, R., Jura, N., Cole, P. A., & Kuriyan, J. (2007). Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450(7170), 741-744. doi: 10.1038/nature05998
Review Papers
Jura, N., Zhang, X., Endres, N. F., Seeliger, M. A., Schindler, T., & Kuriyan, J. (2011). Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms. Molecular Cell, 42(1), 9-22. doi: 10.1016/j.molcel.2011.03.004.
Kovacs, E., Zorn, J. A., Huang, Y., Barros, T., & Kuriyan, J. (2015). A structural perspective on the regulation of the epidermal growth factor receptor. Annual Review of Biochemistry, 84, 739-764. doi: 10.1146/annurev-biochem-060614-034402.
