Friday Lecture Series
Friday, January 22, 2016
3:45 p.m., Caspary Auditorium
Emmanuelle Charpentier, Ph.D.
Professor, Department of Regulation in Infection Biology
Director, Max Planck Institute for Infection Biology;
Visiting Professor, Laboratory for Molecular Infection Medicine Sweden, Umeå University
The Transformative Genome Engineering Technology CRISPR-Cas9: Lessons Learned from bacteria
Recommended Reading
Empirical Articles
Chylinski, K., Le Rhun, A., & Charpentier, E. (2013). The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems. RNA Biology, 10(5), 726-737. doi:10.4161/rna.24321
Fonfara, I., Le Rhun, A., Chylinski, K., Makarova, K. S., Lécrivain, A. L., Bzdrenga, J., … & Charpentier, E. (2014). Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems. Nucleic acids research, 42(4), 2577-2590. doi:10.1093/nar/gkt1074.
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012). A programmable dual-RNA–guided DNA endonuclease in adaptive bacterial immunity. Science, 337(6096), 816-821. doi:10.1126/science.1225829.
Review Papers
Charpentier, E., Richter, H., van der Oost, J., & White, M. F. (2015). Biogenesis pathways of RNA guides in archaeal and bacterial CRISPR-Cas adaptive immunity. FEMS Microbiology Reviews, 39(3), 428-441. doi:10.1093/femsre/fuv023.
Chylinski, K., Makarova, K. S., Charpentier, E., & Koonin, E. V. (2014). Classification and evolution of type II CRISPR-Cas systems. Nucleic acids research, 42(10), 6091-6105. doi:10.1093/nar/gku241
