Evnin Chemical & Structural Biology Seminar Series
(open to the Rockefeller and Tri-Institutional communities)
Tuesday, November 17, 2026
Radhika Subramanian, Ph.D.
Associate Professor, Department of Molecular Biology, Massachusetts General Hospital; Department of Genetics, Harvard Medical School
A GLI-ful Journey through the Primary Cilium
Recommended Readings:
Haque, Farah, et al. “How the non-motile kinesin KIF7 adapts conserved kinesin principles for its function in Hedgehog signaling.” bioRxiv (2026): 2026-02.
Ku, Pei-I., et al. “Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking.” Science Advances 11.11 (2025): eadt5439.
Walker, Madison F., et al. “GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.” PLoS biology 22.8 (2024): e3002685.
Haque, Farah, et al. “Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions.” Nature cell biology 24.7 (2022): 1088-1098.
He, Mu, et al. “The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment.” Nature cell biology 16.7 (2014): 663-672.
