Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, December 5, 2025
Helen Hobbs, M.D.
Professor of Internal Medicine and Molecular Genetics, University of Texas Southwestern Medical Center; Investigator, Howard Hughes Medical Institute
From Ancestry to Biochemistry in Steatotic Liver Disease
The Joshua Lederberg Distinguished Lecture in Molecular Genetics
Recommended Readings:
Wang, Yang, et al. “PNPLA3 (148M) is a gain-of-function mutation that promotes hepatic steatosis by inhibiting ATGL-mediated triglyceride hydrolysis.” Journal of hepatology 82.5 (2025): 871-881.
Das, Avash, et al. “The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.” Proceedings of the National Academy of Sciences 121.6 (2024): e2312291121.
Kozlitina, Julia, et al. “Effect of donor HSD17B13 genotype on patient survival after liver transplant: a retrospective cohort study.” EClinicalMedicine 67 (2024).
Wang, Yang, et al. “PNPLA3, CGI‐58, and inhibition of hepatic triglyceride hydrolysis in mice.” Hepatology 69.6 (2019): 2427-2441.
Cohen, Jonathan C., Jay D. Horton, and Helen H. Hobbs. “Human fatty liver disease: old questions and new insights.” Science 332.6037 (2011): 1519-1523.
Speaker ORCiD: 0000-0002-8700-9897
