Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 30, 2025
Hao Wu, Ph.D.
Senior Investigator, Program in Cellular and Molecular Medicine, Boston Children’s Hospital; Asa and Patricia Springer Professor, Harvard Medical School
Supramolecular Structures that Drive Innate Immunity in Inflammation and Cancer
Recommended Readings:
Fontana, Pietro, et al. “Small-molecule GSDMD agonism in tumors stimulates antitumor immunity without toxicity.” Cell 187.22 (2024): 6165-6181.
Fu, Jianing, Kate Schroder, and Hao Wu. “Mechanistic insights from inflammasome structures.” Nature Reviews Immunology 24.7 (2024): 518-535.
Wang, Longfei, et al. “Structures and functions of the inflammasome engine.” Journal of Allergy and Clinical Immunology 147.6 (2021).
Sharif, Humayun, et al. “Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.” Nature 570.7761 (2019): 338-343.
Lu, Alvin, and Hao Wu. “Structural mechanisms of inflammasome assembly.” The FEBS journal 282.3 (2015): 435-444.
