Hybrid Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, November 1, 2024
Vamsi Mootha, M.D.
Institute Member, Broad Institute of MIT and Harvard; Professor, Department of Medicine, Massachusetts General Hospital; Professor, Department of Systems Biology, Harvard Medical School; Investigator, Howard Hughes Medical Institute
Mitochondrial Genetics, Oxygen, and Their Interaction in Disease
Recommended Readings:
Meisel, Joshua D., et al. “Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism.” Cell 187.3 (2024): 659-675.
Gupta, Rahul, et al. “Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.” Nature 620.7975 (2023): 839-848.
Rogers, Robert S., et al. “Hypoxia extends lifespan and neurological function in a mouse model of aging.” PLoS biology 21.5 (2023): e3002117.
Baik, Alan H., and Isha H. Jain. “Turning the oxygen dial: balancing the highs and lows.” Trends in cell biology 30.7 (2020): 516-536.
Ast, Tslil, et al. “Hypoxia rescues frataxin loss by restoring iron sulfur cluster biogenesis.” Cell 177.6 (2019): 1507-1521.
Jain, Isha H., et al. “Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism.” Cell 181.3 (2020): 716-727.
Jain, Isha H., et al. “Hypoxia as a therapy for mitochondrial disease.” Science 352.6281 (2016): 54-61.
Calvo, Sarah E., and Vamsi K. Mootha. “The mitochondrial proteome and human disease.” Annual review of genomics and human genetics 11.1 (2010): 25-44.
