Hybrid Monday Lecture Series
(open to the Rockefeller community)
Monday, April 8, 2024
Thomas Tuschl, Ph.D.
F. M. Al Akl, M.D. and Margaret Al Akl Professor and Head of the Laboratory of RNA Molecular Biology, The Rockefeller University
Developing Inhibitors of Viral and Metazoan mRNA Cap N7-G Methyl Transferases
Recommended Readings:
Wickramage, Ishani, et al. “SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas.” Cell Host & Microbe 31.7 (2023): 1185-1199.
Wang, Xuanting, et al. “Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.” Communications Biology 5.1 (2022): 154.
Ahmed-Belkacem, Rostom, et al. “Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.” European journal of medicinal chemistry 201 (2020): 112557.
Ramanathan, Anand, G. Brett Robb, and Siu-Hong Chan. “mRNA capping: biological functions and applications.” Nucleic acids research 44.16 (2016): 7511-7526.
Decroly, Etienne, et al. “Conventional and unconventional mechanisms for capping viral mRNA.” Nature Reviews Microbiology 10.1 (2012): 51-65.
