Recommended Readings: Agata Smogorzewska, M.D., Ph.D., April 24

Friday Lecture Series
Friday, April 24, 2015
3:45 p.m., Caspary Auditorium

Agata Smogorzewska, M.D., Ph.D.
Assistant Professor and Head,
Laboratory of Genome Maintenance,
The Rockefeller University

DNA Interstrand Crosslink Repair: from Genetics to Mechanism

Recommended Readings

Empirical Articles

Flynn, E. K., Kamat, A., Lach, F. P., Donovan, F. X., Kimble, D. C., Narisu, N., … & Chandrasekharappa, S. C. (2014). Comprehensive analysis of pathogenic deletion variants in Fanconi anemia genes. Human Mutation, 35(11), 1342-1353. doi:10.1002/humu.22680

Kim, Y., Spitz, G. S., Veturi, U., Lach, F. P., Auerbach, A. D., & Smogorzewska, A. (2013). Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4. Blood, 121(1), 54-63. doi:10.1182/blood-2012-07-441212

Ouyang, J., Garner, E., Hallet, A., Nguyen, H. D., Rickman, K. A., Gill, G., … & Zou, L. (2015). Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance. Molecular Cell, 57(1), 108-122. doi:10.1016/j.molcel.2014.11.015

Wang, R., Persky, N. S., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S. J., & Pavletich, N. P. (2014). Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science, 346(6213), 1127-1130. doi:10.1126/science.1258973

Review Paper

Kottemann, M. C., & Smogorzewska, A. (2013). Fanconi anaemia and the repair of Watson and Crick DNA crosslinks. Nature, 493(7432), 356-363. doi:10.1038/nature11863

Recommended Readings: A. James Hudspeth, M.D., Ph.D., April 27

Monday Lecture Series
Monday, April 27, 2015
4:00 p.m., Carson Family Auditorium (CRC)

A. James Hudspeth, M.D., Ph.D.
F.M. Kirby Professor and Head,
Laboratory of Sensory Neuroscience,
The Rockefeller University
Investigator, Howard Hughes Medical Institute

Making an Effort to Listen: the Active Process of the Cochlea

Recommended Readings

Empirical Articles

Fisher, J. A., Nin, F., Reichenbach, T., Uthaiah, R. C., & Hudspeth, A. J. (2012). The spatial pattern of cochlear amplification. Neuron, 76(5), 989-997. doi:10.1016/j.neuron.2012.09.031

Jacobo, A., & Hudspeth, A. J. (2014). Reaction–diffusion model of hair-bundle morphogenesis. Proceedings of the National Academy of Sciences, 111(43), 15444-15449. doi:10.1073/pnas.1417420111

Maoiléidigh, D. Ó., & Hudspeth, A. J. (2013). Effects of cochlear loading on the motility of active outer hair cells. Proceedings of the National Academy of Sciences, 110(14), 5474-5479. doi:10.1073/pnas.1302911110

Nin, F., Reichenbach, T., Fisher, J. A., & Hudspeth, A. J. (2012). Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea. Proceedings of the National Academy of Sciences, 109(51), 21076-21080. doi:10.1073/pnas.1219379110

Review Papers

Hudspeth, A. J. (2015). The energetic ear. Daedalus, 144(1), 42-52. doi:10.1162/DAED_a_00316

Hudspeth, A. J. (2014). Integrating the active process of hair cells with cochlear function. Nature Reviews Neuroscience, 15(9), 600-614. doi:10.1038/nrn3786