Friday Lecture Series
(open to the Rockefeller and Tri-Institutional communities)
Friday, May 8, 2026
William Kaelin, M.D.
Sidney Farber Professor of Medicine, Dana-Farber Cancer Institute; Harvard Medical School; Investigator, Howard Hughes Medical Institute
The von Hippel-Lindau Hereditary Cancer Syndrome: Insights into Cancer, Oxygen Sensing, and Drugging the Undruggable
The Annual Cancer Biology Lecture
Recommended Readings:
Abu-Remaileh, Muhannad, et al. “Targeting of HIF2-driven cachexia in kidney cancer.” Nature medicine 32.1 (2026): 245-257.
Shirole, Nitin H., et al. “Requirement for cyclin D1 underlies cell-autonomous HIF2 dependence in kidney cancer.” Cancer discovery 15.7 (2025): 1484-1504.
Jiang, Qinqin, et al. “HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.” Cell 188.7 (2025): 1807-1827.
Abu-Remaileh, Muhannad, et al. “Total loss of VHL gene function impairs neuroendocrine cancer cell fitness due to excessive HIF2α activity.” Proceedings of the National Academy of Sciences 121.40 (2024): e2410356121.
Shirole, Nitin H, and Kaelin, William G. “von-Hippel Lindau and Hypoxia-Inducible Factor at the Center of Renal Cell Carcinoma Biology.” Hematology/Oncology Clinics of North America 37.5 (2023): 809-825.
