Chemical & Structural Biology Seminar Series
(open to the Rockefeller and Tri-Institutional communities)
Wednesday, April 30, 2025
Tom Muir, Ph.D.
Van Zandt Williams Jr. Class of 1965 Professor of Chemistry, Princeton University
Harnessing Inteins in Synthetic Biology From Triggers to Logic Gates
Recommended Readings:
Kofoed, Christian, et al. “Cell surface sculpting using logic-gated protein actuators.” bioRxiv (2023).
Burton, Antony J., et al. “Live-cell protein engineering with an ultra-short split intein.” Proceedings of the National Academy of Sciences 117.22 (2020): 12041-12049.
Stevens, Adam J., et al. “A promiscuous split intein with expanded protein engineering applications.” Proceedings of the National Academy of Sciences 114.32 (2017): 8538-8543.
Shah, Neel H., and Tom W. Muir. “Inteins: nature’s gift to protein chemists.” Chemical science 5.2 (2014): 446-461.
Eryilmaz, Ertan, et al. “Structural and dynamical features of inteins and implications on protein splicing.” Journal of Biological Chemistry 289.21 (2014): 14506-14511.
